{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(5)"],"submitter":["Bass LS"],"pubmed_abstract":["<h4>Background</h4>Collagen-rich fibrous septae and subcutaneous adipose protrusions play a role in cellulite pathophysiology. Collagenase clostridium histolyticum-aaes (CCH-aaes) injection causes enzymatic release of septae to resolve cellulite depressions and create a skin smoothing effect. This analysis pooled data from two identically designed, phase-3, randomized, double-blind, placebo-controlled studies to examine the efficacy and safety of CCH-aaes.<h4>Methods</h4>Adult women with moderate/severe cellulite (3-4 on Clinician Reported Photonumeric Cellulite Severity Scale and Patient Reported Photonumeric Cellulite Severity Scale) on the buttocks received up to three treatment sessions (Days 1, 22, and 43) of subcutaneous CCH-aaes 0.84 mg or placebo per treatment area. Composite and i"],"journal":["Plastic and reconstructive surgery. Global open"],"pagination":["e4306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9132528"],"repository":["biostudies-literature"],"pubmed_title":["Collagenase Clostridium Histolyticum-aaes for Treatment of Cellulite: A Pooled Analysis of Two Phase-3 Trials."],"pmcid":["PMC9132528"],"pubmed_authors":["Bass LS","Clark J","Davis MW","Kaminer MS","McLane MP","Joseph JH","Vijayan S","Hurley D","Goldman MP","Katz BE","Peddy K","Kaufman-Janette J","Fabi SG","Young VL","Gold MH","Schlessinger J","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"Collagenase Clostridium Histolyticum-aaes for Treatment of Cellulite: A Pooled Analysis of Two Phase-3 Trials.","description":"<h4>Background</h4>Collagen-rich fibrous septae and subcutaneous adipose protrusions play a role in cellulite pathophysiology. Collagenase clostridium histolyticum-aaes (CCH-aaes) injection causes enzymatic release of septae to resolve cellulite depressions and create a skin smoothing effect. This analysis pooled data from two identically designed, phase-3, randomized, double-blind, placebo-controlled studies to examine the efficacy and safety of CCH-aaes.<h4>Methods</h4>Adult women with moderate/severe cellulite (3-4 on Clinician Reported Photonumeric Cellulite Severity Scale and Patient Reported Photonumeric Cellulite Severity Scale) on the buttocks received up to three treatment sessions (Days 1, 22, and 43) of subcutaneous CCH-aaes 0.84 mg or placebo per treatment area. Composite and i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-10T01:43:26.456Z","creation":"2025-02-19T02:58:18.574Z"},"accession":"S-EPMC9132528","cross_references":{"pubmed":["35646496"],"doi":["10.1097/GOX.0000000000004306"]}}