{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Kalischuk M"],"funding":["Department of Education and Training | Australian Research Council","Gouvernement du Canada | Agriculture and Agri-Food Canada","Fraunhofer-Gesellschaft","Australian Education International, Australian Government"],"pubmed_abstract":["Immunity cell-surface receptors Ve1 and Ve2 protect against fungi of the genus Verticillium causing early dying, a worldwide disease in many crops. Characterization of microbe-associated molecular pattern immunity receptors has advanced our understanding of disease resistance but signal amplification remains elusive. Here, we report that transgenic plants expressing Ve1 and Ve2 together, reduced pathogen titres by a further 90% compared to plants expressing only Ve1 or Ve2. Confocal and immunoprecipitation confirm that the two receptors associate to form heteromeric complexes in the absence of the ligand and positively regulate signaling. Bioassays show that the Ve1Ve2 complex activates race-specific amplified immunity to the pathogen through a rapid burst of reactive oxygen species (ROS)."],"journal":["Communications biology"],"pagination":["497"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9132969"],"repository":["biostudies-literature"],"pubmed_title":["Amplification of cell signaling and disease resistance by an immunity receptor Ve1Ve2 heterocomplex in plants."],"pmcid":["PMC9132969"],"pubmed_authors":["Fusaro AF","Kalischuk M","Wijekoon CP","Waterhouse PM","Muller B","Prufer D","Kawchuk L"],"additional_accession":[]},"is_claimable":false,"name":"Amplification of cell signaling and disease resistance by an immunity receptor Ve1Ve2 heterocomplex in plants.","description":"Immunity cell-surface receptors Ve1 and Ve2 protect against fungi of the genus Verticillium causing early dying, a worldwide disease in many crops. Characterization of microbe-associated molecular pattern immunity receptors has advanced our understanding of disease resistance but signal amplification remains elusive. Here, we report that transgenic plants expressing Ve1 and Ve2 together, reduced pathogen titres by a further 90% compared to plants expressing only Ve1 or Ve2. Confocal and immunoprecipitation confirm that the two receptors associate to form heteromeric complexes in the absence of the ligand and positively regulate signaling. Bioassays show that the Ve1Ve2 complex activates race-specific amplified immunity to the pathogen through a rapid burst of reactive oxygen species (ROS).","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-09T18:55:24.365Z","creation":"2025-04-05T20:41:24.138Z"},"accession":"S-EPMC9132969","cross_references":{"pubmed":["35614138"],"doi":["10.1038/s42003-022-03439-0"]}}