{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Banda NK"],"funding":["Foundation for the National Institutes of Health","Medical Research Council","NIAMS NIH HHS"],"pagination":["2482-2496"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9133225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["208(11)"],"pubmed_abstract":["Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial hyperplasia and inflammation. The finding of autoantibodies in seropositive RA suggests that complement system activation might play a pathophysiologic role due to the local presence of immune complexes in the joints. Our first objective was to explore the Pathobiology of Early Arthritis Cohort (PEAC) mRNA sequencing data for correlations between clinical disease severity as measured by DAS28-ESR (disease activity score in 28 joints for erythrocyte sedimentation rate) and complement system gene expression, both in the synovium and in blood. Our second objective was to determine the biodistribution using multiplex immunohistochemical staining of specific complement activation proteins and inhibitors from subjects i"],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features."],"pmcid":["PMC9133225"],"funding_grant_id":["G0800648","R01 AR051749","UKDRI-3002","AR51749","R56 AR051749"],"pubmed_authors":["Morgan BP","Holers VM","Deane KD","Goldman K","Bemis EA","Pitzalis C","Strickland C","Seifert J","Banda NK","Jordan K","Moreland LW","Lewis MJ"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features.","description":"Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial hyperplasia and inflammation. The finding of autoantibodies in seropositive RA suggests that complement system activation might play a pathophysiologic role due to the local presence of immune complexes in the joints. Our first objective was to explore the Pathobiology of Early Arthritis Cohort (PEAC) mRNA sequencing data for correlations between clinical disease severity as measured by DAS28-ESR (disease activity score in 28 joints for erythrocyte sedimentation rate) and complement system gene expression, both in the synovium and in blood. Our second objective was to determine the biodistribution using multiplex immunohistochemical staining of specific complement activation proteins and inhibitors from subjects i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-06-04T04:39:43.073Z","creation":"2025-04-03T21:30:26.788Z"},"accession":"S-EPMC9133225","cross_references":{"pubmed":["35500934"],"doi":["10.4049/jimmunol.2101170"]}}