biostudies-literatureRodriguez CPNHLBI NIH HHS741-749https://www.ebi.ac.uk/biostudies/studies/S-EPMC9133972biostudies-literatureUnknown31(5)Background: Multiparity is a risk factor for cardiovascular disease (CVD). However, the mechanisms of this relationship are unknown. Adipokines may predispose multiparous women to certain cardiometabolic complications that can increase their risk of future CVD. Materials and Methods: We studied 973 female participants of the Multi-Ethnic Study of Atherosclerosis free of CVD, who had complete data on parity and adipokines measured at Examination 2 or 3 (randomly assigned). Parity was categorized as nulliparity, 1-2, 3-4, and ≥5 live births. Multivariable linear regression was used to evaluate the association of parity with leptin, resistin, and adiponectin levels. Results: The women had mean age of 65 ± 9 years. After adjustment for age, race/ethnicJournal of women's health (2002)The Association Between Multiparity and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis.PMC9133972T32 HL007024R01 HL146907Bertoni AGNdumele CEEchouffo Tcheugui JAllison MAMichos EDRodriguez CPOgunmoroti OQuispe RMinhas ASOsibogun OfalseThe Association Between Multiparity and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis.Background: Multiparity is a risk factor for cardiovascular disease (CVD). However, the mechanisms of this relationship are unknown. Adipokines may predispose multiparous women to certain cardiometabolic complications that can increase their risk of future CVD. Materials and Methods: We studied 973 female participants of the Multi-Ethnic Study of Atherosclerosis free of CVD, who had complete data on parity and adipokines measured at Examination 2 or 3 (randomly assigned). Parity was categorized as nulliparity, 1-2, 3-4, and ≥5 live births. Multivariable linear regression was used to evaluate the association of parity with leptin, resistin, and adiponectin levels. Results: The women had mean age of 65 ± 9 years. After adjustment for age, race/ethnic2022-01-01T00:00:00Z2022 May2026-05-09T22:37:28.768Z2025-02-19T03:25:51.464ZS-EPMC91339723474764910.1089/jwh.2021.0091