{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Li X"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["<h4>Objectives</h4>To characterize two plasmids co-harboring carbapenem resistance genes and <i>tmexCD2-toprJ2</i> in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) strains.<h4>Methods</h4>Two clinical CRKP strains were isolated and characterized by antimicrobial susceptibility testing, conjugation assays, whole-genome sequencing, and bioinformatics analysis.<h4>Results</h4>The two CRKP strains NB4 and NB5 were both resistant to imipenem, meropenem and tigecycline. Whole-genome sequencing revealed that two CRKP strains belonged to the ST11 type and carried multiple resistance genes. The <i>tmexCD2-toprJ2</i> clusters in both strains were located on the IncFIB(Mar)-like/HI1B-like group of hybrid plasmids, which co-harbored the metallo-β-lactamase gene <i>bla</i><sub>NDM-1</sub>. I"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["902774"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9134201"],"repository":["biostudies-literature"],"pubmed_title":["Emergence of Plasmids Co-Harboring Carbapenem Resistance Genes and <i>tmexCD2-toprJ2</i> in Sequence Type 11 Carbapenem Resistant <i>Klebsiella pneumoniae</i> Strains."],"pmcid":["PMC9134201"],"pubmed_authors":["Zou X","Li X","Ma Q","Jin X","Zhang X","Huang H","Wang W","Hu Q","Tu Y"],"additional_accession":[]},"is_claimable":false,"name":"Emergence of Plasmids Co-Harboring Carbapenem Resistance Genes and <i>tmexCD2-toprJ2</i> in Sequence Type 11 Carbapenem Resistant <i>Klebsiella pneumoniae</i> Strains.","description":"<h4>Objectives</h4>To characterize two plasmids co-harboring carbapenem resistance genes and <i>tmexCD2-toprJ2</i> in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) strains.<h4>Methods</h4>Two clinical CRKP strains were isolated and characterized by antimicrobial susceptibility testing, conjugation assays, whole-genome sequencing, and bioinformatics analysis.<h4>Results</h4>The two CRKP strains NB4 and NB5 were both resistant to imipenem, meropenem and tigecycline. Whole-genome sequencing revealed that two CRKP strains belonged to the ST11 type and carried multiple resistance genes. The <i>tmexCD2-toprJ2</i> clusters in both strains were located on the IncFIB(Mar)-like/HI1B-like group of hybrid plasmids, which co-harbored the metallo-β-lactamase gene <i>bla</i><sub>NDM-1</sub>. I","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-09T19:51:57.97Z","creation":"2024-11-20T23:04:20.316Z"},"accession":"S-EPMC9134201","cross_references":{"pubmed":["35646740"],"doi":["10.3389/fcimb.2022.902774"]}}