biostudies-literaturePicard EClaude D Pepper Older Americans Independence CenterNIA NIH HHSHealth Sciences North Chair in Healthy AgingMichael G DeGroote Chair in Infectious DiseasesLung Health FoundationTravelers Chair in Geriatrics and GerontologyNIA/National Institutes of Health26https://www.ebi.ac.uk/biostudies/studies/S-EPMC9134679biostudies-literatureUnknown19(1)<h4>Background</h4>With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called "inflammaging" contributes to the risk of adverse outcomes in older adults. We sought to determine whether markers of systemic inflammation were associated with antibody responses to the seasonal influenza vaccine.<h4>Results</h4>Over four seasons, hemagglutination inhibition antibody titres and ex vivo bulk peripheral blood mononuclear cell (PBMC) responses to live influenza viruses assessed via interferon (IFN)-γ/interleukin (IL)-10 production, were measured pre- and 4-weeks post-vaccination in young adults (n = 79) and older adults randomized to Immunity & ageing : I & AMarkers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.PMC9134679P30 AG067988R01 AG048023Haynes LVerschoor CPKuchel GAMcElhaney JEPicard ELoeb MPawelec GArmstrong SAndrew MKfalseMarkers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.<h4>Background</h4>With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called "inflammaging" contributes to the risk of adverse outcomes in older adults. We sought to determine whether markers of systemic inflammation were associated with antibody responses to the seasonal influenza vaccine.<h4>Results</h4>Over four seasons, hemagglutination inhibition antibody titres and ex vivo bulk peripheral blood mononuclear cell (PBMC) responses to live influenza viruses assessed via interferon (IFN)-γ/interleukin (IL)-10 production, were measured pre- and 4-weeks post-vaccination in young adults (n = 79) and older adults randomized to 2022-01-01T00:00:00Z2022 May2026-05-09T16:35:19.693Z2024-11-13T08:34:58.573ZS-EPMC91346793561911710.1186/s12979-022-00284-x