biostudies-literatureKiss TBLRD VANEI NIH HHSNIA NIH HHSNCI NIH HHSNINDS NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHSNational Institute on Aging953-981https://www.ebi.ac.uk/biostudies/studies/S-EPMC9135944biostudies-literatureUnknown44(2)Vascular aging has a central role in the pathogenesis of cardiovascular diseases contributing to increased mortality of older adults. There is increasing evidence that, in addition to the documented role of cell-autonomous mechanisms of aging, cell-nonautonomous mechanisms also play a critical role in the regulation of vascular aging processes. Our recent transcriptomic studies (Kiss T. et al. Geroscience. 2020;42(2):727-748) demonstrated that circulating anti-geronic factors from young blood promote vascular rejuvenation in aged mice. The present study was designed to expand upon the results of this study by testing the hypothesis that circulating pro-geronic factors also contribute to the genesis of vascular aging phenotypes. To test this hypothesis, through heterochronic parabiosis, we GeroScienceOld blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.PMC9135944U54 GM104938P30 EY001792R01AG070915T32 AG052363R01 AG068295R01 AG055395K01 AG073614K01AG073614P20 GM125528RF1 AG072295I01 BX005592P30AG050911P30 GM110766R01 EY010609T32AG052363R01AG055395R01 NS100782P30AG038072P30 AG050911P30 AG038072R01 CA255840P20 GM103447R01 AG070915R01AG068295RF1AG072295Benyo ZGarman LYabluchanskiy AKiss TBalasubramanian PMukli PUngvari ZTarantini SCsiszar AUngvari ANyul-Toth AGulej RCsipo TConley SMHuffman DMWren JDfalseOld blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.Vascular aging has a central role in the pathogenesis of cardiovascular diseases contributing to increased mortality of older adults. There is increasing evidence that, in addition to the documented role of cell-autonomous mechanisms of aging, cell-nonautonomous mechanisms also play a critical role in the regulation of vascular aging processes. Our recent transcriptomic studies (Kiss T. et al. Geroscience. 2020;42(2):727-748) demonstrated that circulating anti-geronic factors from young blood promote vascular rejuvenation in aged mice. The present study was designed to expand upon the results of this study by testing the hypothesis that circulating pro-geronic factors also contribute to the genesis of vascular aging phenotypes. To test this hypothesis, through heterochronic parabiosis, we 2022-01-01T00:00:00Z2022 Apr2026-05-07T03:17:43.719Z2025-02-19T02:59:10.483ZS-EPMC91359443512476410.1007/s11357-022-00519-1