{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiss T"],"funding":["National Institute of Neurological Disorders and Stroke","NIA NIH HHS","NINDS NIH HHS","National Institute on Aging"],"pagination":["661-681"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9135953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. The finding that treatment with senolytic drugs improves cognitive performance of aged laboratory mice suggests that increased cellular senescence is causally linked to age-related cognitive decline. The relationship between senescent cells and their relative locations within the brain is critical to understanding the pathology of age-related cognitive decline and dementia. To assess spatial distribution of cellular senescence in the aged mouse brain, spatially resolved whole transcriptome mRNA expression was analyzed in sections of brains derived from young (3 months old) and aged (28 months old) C57BL/6 mice while capturing histological information in the same tissue section. Usi"],"journal":["GeroScience"],"pubmed_title":["Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain."],"pmcid":["PMC9135953"],"funding_grant_id":["R01-AG047879","R01-NS100782","R01 AG068295","R01-NS056218","R0-AG038747","R01-AG055395"],"pubmed_authors":["Garman L","Yabluchanskiy A","Faakye J","Kiss T","Balasubramanian P","Ungvari Z","Tarantini S","Ahire C","Csiszar A","Ungvari A","Nyul-Toth A","Gulej R","Wiley G","DelFavero J"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.","description":"There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. The finding that treatment with senolytic drugs improves cognitive performance of aged laboratory mice suggests that increased cellular senescence is causally linked to age-related cognitive decline. The relationship between senescent cells and their relative locations within the brain is critical to understanding the pathology of age-related cognitive decline and dementia. To assess spatial distribution of cellular senescence in the aged mouse brain, spatially resolved whole transcriptome mRNA expression was analyzed in sections of brains derived from young (3 months old) and aged (28 months old) C57BL/6 mice while capturing histological information in the same tissue section. Usi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-18T20:33:51.888Z","creation":"2025-02-19T03:22:57.716Z"},"accession":"S-EPMC9135953","cross_references":{"pubmed":["35098444"],"doi":["10.1007/s11357-022-00521-7"]}}