{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Hu J"],"pubmed_abstract":["<h4>Objective</h4>To evaluate the predictive value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the quantitative assessment of conventional chemotherapy-activated immune responses in mouse tumor models and clinics.<h4>Methods</h4>A total of 19 subcutaneous tumor-bearing mice were randomly divided into treated and control groups. Both groups had orderly IVIM DWI examinations before and on days 6 and 12 after the administration of cyclophosphamide (CPA) or saline. Pathologic examinations were performed, including HE staining and immunohistochemistry (IHC). The expressions of immune-related genes in the tumor were measured by qPCR. In addition, six patients with breast cancer requiring neoadjuvant chemotherapy (NACT) also underwent functional MRI examinations and"],"journal":["Frontiers in oncology"],"pagination":["796936"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9136146"],"repository":["biostudies-literature"],"pubmed_title":["Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging for Monitoring the Immune Response of Immunogenic Chemotherapy."],"pmcid":["PMC9136146"],"pubmed_authors":["Du B","Hu J","Yin P","Yu X","Cai X"],"additional_accession":[]},"is_claimable":false,"name":"Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging for Monitoring the Immune Response of Immunogenic Chemotherapy.","description":"<h4>Objective</h4>To evaluate the predictive value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in the quantitative assessment of conventional chemotherapy-activated immune responses in mouse tumor models and clinics.<h4>Methods</h4>A total of 19 subcutaneous tumor-bearing mice were randomly divided into treated and control groups. Both groups had orderly IVIM DWI examinations before and on days 6 and 12 after the administration of cyclophosphamide (CPA) or saline. Pathologic examinations were performed, including HE staining and immunohistochemistry (IHC). The expressions of immune-related genes in the tumor were measured by qPCR. In addition, six patients with breast cancer requiring neoadjuvant chemotherapy (NACT) also underwent functional MRI examinations and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T18:19:25.212Z","creation":"2025-04-06T02:26:33.918Z"},"accession":"S-EPMC9136146","cross_references":{"pubmed":["35646652"],"doi":["10.3389/fonc.2022.796936"]}}