{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nystrom S"],"funding":["Vetenskapsrådet"],"pagination":["8945-8950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9136918"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(20)"],"pubmed_abstract":["SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the S-protein. All seven peptides in isolation formed aggregates during incubation at 37 °C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Full-length folded S-pr"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Amyloidogenesis of SARS-CoV-2 Spike Protein."],"pmcid":["PMC9136918"],"funding_grant_id":["2019-04405"],"pubmed_authors":["Nystrom S","Hammarstrom P"],"additional_accession":[]},"is_claimable":false,"name":"Amyloidogenesis of SARS-CoV-2 Spike Protein.","description":"SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 spike protein (S-protein). Amyloid fibril assays of peptide library mixtures and theoretical predictions identified seven amyloidogenic sequences within the S-protein. All seven peptides in isolation formed aggregates during incubation at 37 °C. Three 20-amino acid long synthetic spike peptides (sequence 192-211, 601-620, 1166-1185) fulfilled three amyloid fibril criteria: nucleation dependent polymerization kinetics by ThT, Congo red positivity, and ultrastructural fibrillar morphology. Full-length folded S-pr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-09T21:54:56.362Z","creation":"2025-04-04T13:30:11.513Z"},"accession":"S-EPMC9136918","cross_references":{"pubmed":["35579205"],"doi":["10.1021/jacs.2c03925"]}}