{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kiiskila JM"],"funding":["Academy of Finland","Sigrid Juséliuksen Säätiö","Novo Nordisk Foundation Center for Basic Metabolic Research","Novo Nordisk Fonden"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9137050"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>Endurance exercise training promotes the catabolism of branched-chain amino acids (BCAAs) in skeletal muscles. We have previously shown that mitochondrial DNA (mtDNA) haplogroups J and K are markers of low responders in endurance training. In this paper, we hypothesize that BCAA catabolism is a surrogate marker of lower respiratory chain activity attributed to these haplogroups. We evaluated whether exercise-induced changes in amino acid concentrations differ between subjects harbouring mtDNA haplogroups J or K and those with non-JK haplogroups.<h4>Methods</h4>Finnish male conscripts (N = 633) undertook the 12-min Cooper running test at the beginning and end of their military service. The intervention during the service mainly included endurance aerobic exercise and spor"],"journal":["BMC sports science, medicine & rehabilitation"],"pubmed_title":["Association between mitochondrial DNA haplogroups J and K, serum branched-chain amino acids and lowered capability for endurance exercise."],"pmcid":["PMC9137050"],"funding_grant_id":["Academy of Finland","NNF17OC0026062","Sigrid Juséliuksen Säätiö","Novo Nordisk Foundation Center for Basic Metabolic Research"],"pubmed_authors":["Mikkola I","Jokelainen JJ","Majamaa K","Harkonen P","Hassinen IE","Kettunen J","Keinanen-Kiukaanniemi S","Kiiskila JM","Kytovuori L","Perola M"],"additional_accession":[]},"is_claimable":false,"name":"Association between mitochondrial DNA haplogroups J and K, serum branched-chain amino acids and lowered capability for endurance exercise.","description":"<h4>Background</h4>Endurance exercise training promotes the catabolism of branched-chain amino acids (BCAAs) in skeletal muscles. We have previously shown that mitochondrial DNA (mtDNA) haplogroups J and K are markers of low responders in endurance training. In this paper, we hypothesize that BCAA catabolism is a surrogate marker of lower respiratory chain activity attributed to these haplogroups. We evaluated whether exercise-induced changes in amino acid concentrations differ between subjects harbouring mtDNA haplogroups J or K and those with non-JK haplogroups.<h4>Methods</h4>Finnish male conscripts (N = 633) undertook the 12-min Cooper running test at the beginning and end of their military service. The intervention during the service mainly included endurance aerobic exercise and spor","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-06T03:18:48.693Z","creation":"2025-04-05T20:40:56.534Z"},"accession":"S-EPMC9137050","cross_references":{"pubmed":["35619160"],"doi":["10.1186/s13102-022-00485-3"]}}