biostudies-literatureAngelucci CBItalian Ministry of Health1304https://www.ebi.ac.uk/biostudies/studies/S-EPMC9137499biostudies-literatureUnknown12(10)<i>Brucella ceti</i>, a zoonotic pathogen of major concern to cetacean health and conservation, is responsible for severe meningo-encephalitic/myelitic lesions in striped dolphins (<i>Stenella coeruleoalba</i>), often leading to their stranding and death. This study investigated, for the first time, the cellular prion protein (PrP^c) expression in the brain tissue from <i>B. ceti</i>-infected, neurobrucellosis-affected striped dolphins. Seven <i>B. ceti</i>-infected, neurobrucellosis-affected striped dolphins, found stranded along the Italian coastline (6) and in the Canary Islands (1), were investigated, along with five <i>B. ceti</i>-uninfected striped dolphins from the coast of Italy, carrying no brain lesions, which served as negative controls. Western Blot (WB) and immunohisAnimals : an open access journal from MDPICellular Prion Protein Expression in the Brain Tissue from <i>Brucella ceti</i>-Infected Striped Dolphins (<i>Stenella coeruleoalba</i>).PMC9137499IZSAM 03/16/RC.Tittarelli MGiacominelli-Stuffler RBaffoni MDi Francesco CEFernandez AGrattarola CPetrella ASierra EDi Guardo GDi Renzo LAngelucci CBDi Francesco GMazzariol SfalseCellular Prion Protein Expression in the Brain Tissue from <i>Brucella ceti</i>-Infected Striped Dolphins (<i>Stenella coeruleoalba</i>).<i>Brucella ceti</i>, a zoonotic pathogen of major concern to cetacean health and conservation, is responsible for severe meningo-encephalitic/myelitic lesions in striped dolphins (<i>Stenella coeruleoalba</i>), often leading to their stranding and death. This study investigated, for the first time, the cellular prion protein (PrP^c) expression in the brain tissue from <i>B. ceti</i>-infected, neurobrucellosis-affected striped dolphins. Seven <i>B. ceti</i>-infected, neurobrucellosis-affected striped dolphins, found stranded along the Italian coastline (6) and in the Canary Islands (1), were investigated, along with five <i>B. ceti</i>-uninfected striped dolphins from the coast of Italy, carrying no brain lesions, which served as negative controls. Western Blot (WB) and immunohis2022-01-01T00:00:00Z2022 May2025-04-04T10:42:30.279Z2025-04-04T10:42:30.279ZS-EPMC91374993562515010.3390/ani12101304