{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morgan R"],"funding":["NIDA NIH HHS","NIMHD NIH HHS","National Institute on Drug Abuse","National Institute on Minority Health and Health Disparities"],"pagination":["625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9137560"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(5)"],"pubmed_abstract":["Prostate cancer is one of the most prevalent cancers worldwide, particularly affecting men living a western lifestyle and of African descent, suggesting risk factors that are genetic, environmental, and socioeconomic in nature. In the USA, African American (AA) men are disproportionately affected, on average suffering from a higher grade of the disease and at a younger age compared to men of European descent (EA). Fusion genes are chimeric products formed by the merging of two separate genes occurring as a result of chromosomal structural changes, for example, inversion or trans/cis-splicing of neighboring genes. They are known drivers of cancer and have been identified in 20% of cancers. Improvements in genomics technologies such as RNA-sequencing coupled with better algorithms for predic"],"journal":["Biology"],"pubmed_title":["Fusion Genes in Prostate Cancer: A Comparison in Men of African and European Descent."],"pmcid":["PMC9137560"],"funding_grant_id":["1U01DA045300-01A1","U54MD010706-CHH"],"pubmed_authors":["Wolf B","Hughes Halbert C","Keeley D","Savage SJ","Gattoni-Celli S","Allott EH","Hardiman G","Morgan R","Hazard ES"],"additional_accession":[]},"is_claimable":false,"name":"Fusion Genes in Prostate Cancer: A Comparison in Men of African and European Descent.","description":"Prostate cancer is one of the most prevalent cancers worldwide, particularly affecting men living a western lifestyle and of African descent, suggesting risk factors that are genetic, environmental, and socioeconomic in nature. In the USA, African American (AA) men are disproportionately affected, on average suffering from a higher grade of the disease and at a younger age compared to men of European descent (EA). Fusion genes are chimeric products formed by the merging of two separate genes occurring as a result of chromosomal structural changes, for example, inversion or trans/cis-splicing of neighboring genes. They are known drivers of cancer and have been identified in 20% of cancers. Improvements in genomics technologies such as RNA-sequencing coupled with better algorithms for predic","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-04-08T10:04:34.612Z","creation":"2025-04-20T03:06:39.559Z"},"accession":"S-EPMC9137560","cross_references":{"pubmed":["35625354"],"doi":["10.3390/biology11050625"]}}