{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Balta I"],"funding":["Environtech"],"pagination":["974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9137680"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(5)"],"pubmed_abstract":["Nematopsis messor infections severely impact on shrimp’s health with devastating economic consequences on shrimp farming. In a shrimp primary intestinal cells (SGP) model of infection, a sub-inhibitory concentration (0.5%) of natural antimicrobials (Aq) was able to reduce the ability of N. messor to infect (p < 0.0001). To prevent N. messor infection of SGP cells, Aq inhibits host actin polymerization and restores tight junction integrity (TEER) and the expression of Zo-1 and occluding. The oxidative burst, caused by N. messor infection, is attenuated by Aq through the inhibition of NADPH-produced H2O2. Simultaneous to the reduction in H2O2 released, the activity of catalase (CAT) and superoxide dismutase (SOD) were also significantly increase (p < 0.0001). The antimicrobial mixture inacti"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["The Antioxidant Effect of Natural Antimicrobials in Shrimp Primary Intestinal Cells Infected with <i>Nematopsis messor</i>."],"pmcid":["PMC9137680"],"funding_grant_id":["49560"],"pubmed_authors":["Gundogdu O","Balta I","Ward P","Venig A","Butucel E","Stef D","Corcionivoschi N","Koyun OY","Callaway TR","Deshaies M","Stef L","Pet I","Gradisteanu Pircalabioru G"],"additional_accession":[]},"is_claimable":false,"name":"The Antioxidant Effect of Natural Antimicrobials in Shrimp Primary Intestinal Cells Infected with <i>Nematopsis messor</i>.","description":"Nematopsis messor infections severely impact on shrimp’s health with devastating economic consequences on shrimp farming. In a shrimp primary intestinal cells (SGP) model of infection, a sub-inhibitory concentration (0.5%) of natural antimicrobials (Aq) was able to reduce the ability of N. messor to infect (p < 0.0001). To prevent N. messor infection of SGP cells, Aq inhibits host actin polymerization and restores tight junction integrity (TEER) and the expression of Zo-1 and occluding. The oxidative burst, caused by N. messor infection, is attenuated by Aq through the inhibition of NADPH-produced H2O2. Simultaneous to the reduction in H2O2 released, the activity of catalase (CAT) and superoxide dismutase (SOD) were also significantly increase (p < 0.0001). The antimicrobial mixture inacti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-25T16:57:35.37Z","creation":"2024-11-05T17:01:54.733Z"},"accession":"S-EPMC9137680","cross_references":{"pubmed":["35624838"],"doi":["10.3390/antiox11050974"]}}