{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Caballero E"],"funding":["Junta de Castilla y León","Ministerio de Ciencia e Innovación, Spain","Junta de Castilla y León, Spain"],"pagination":["1153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9138537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(5)"],"pubmed_abstract":["The molecular basis of amyloid toxicity in Alzheimer's disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca2+ influx, mitochondrial Ca2+ overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary Ca2+ entry pathways are unclear. We studied Ca2+ entry pathways induced by Aβ oligomers in rat hippocampal and cerebellar neurons. Aβ oligomers induce Ca2+ entry in neurons. Ca2+ responses to Aβ oligomers are large after synaptic networking and prevented by blockers of synaptic transmission. In contrast, in neurons devoid of synaptic connections, Ca2+ responses to Aβ oligomers are small and prevented only by blockers of amyloid channels (NA7) and NMDA receptors (MK801). A combin"],"journal":["Biomedicines"],"pubmed_title":["Amyloid Beta Oligomers-Induced Ca2+ Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation."],"pmcid":["PMC9138537"],"funding_grant_id":["CCVC8485","VA294P18","RTI2018-099298-B-10"],"pubmed_authors":["Nunez L","Villalobos C","Hernando-Perez E","Calvo-Rodriguez M","Tapias V","Caballero E"],"additional_accession":[]},"is_claimable":false,"name":"Amyloid Beta Oligomers-Induced Ca2+ Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation.","description":"The molecular basis of amyloid toxicity in Alzheimer's disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca2+ influx, mitochondrial Ca2+ overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary Ca2+ entry pathways are unclear. We studied Ca2+ entry pathways induced by Aβ oligomers in rat hippocampal and cerebellar neurons. Aβ oligomers induce Ca2+ entry in neurons. Ca2+ responses to Aβ oligomers are large after synaptic networking and prevented by blockers of synaptic transmission. In contrast, in neurons devoid of synaptic connections, Ca2+ responses to Aβ oligomers are small and prevented only by blockers of amyloid channels (NA7) and NMDA receptors (MK801). A combin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-21T17:32:32.489Z","creation":"2025-04-05T16:40:23.722Z"},"accession":"S-EPMC9138537","cross_references":{"pubmed":["35625890"],"doi":["10.3390/biomedicines10051153"]}}