{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hahn L"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9139023"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Preeclampsia (PE) is a severe pregnancy disorder with a pathophysiology not yet completely understood and without curative therapy. The histone modifications H3K4me<sup>3</sup> and H3K9ac, as well as galectin-2 (Gal-2), are known to be decreased in PE. To gain a better understanding of the development of PE, the influence of Gal-2 on histone modification in trophoblasts and in syncytialisation was investigated. Immunohistochemical stains of 13 PE and 13 control placentas were correlated, followed by cell culture experiments. An analysis of H3K4me<sup>3</sup> and H3K9ac was conducted, as well as cell fusion staining with E-cadherin and β-catenin-both after incubation with Gal-2. The expression of H3K4me<sup>3</sup> and H3K9ac correlated significantly with the expression of Gal-2. Furthermor"],"journal":["Biomolecules"],"pubmed_title":["Gal-2 Increases H3K4me<sup>3</sup> and H3K9ac in Trophoblasts and Preeclampsia."],"pmcid":["PMC9139023"],"funding_grant_id":["413635475"],"pubmed_authors":["Corradini S","Mahner S","Jeschke U","Meister S","Beyer S","Hasbargen U","Mannewitz M","Kolben T","Burges A","Hahn L"],"additional_accession":[]},"is_claimable":false,"name":"Gal-2 Increases H3K4me<sup>3</sup> and H3K9ac in Trophoblasts and Preeclampsia.","description":"Preeclampsia (PE) is a severe pregnancy disorder with a pathophysiology not yet completely understood and without curative therapy. The histone modifications H3K4me<sup>3</sup> and H3K9ac, as well as galectin-2 (Gal-2), are known to be decreased in PE. To gain a better understanding of the development of PE, the influence of Gal-2 on histone modification in trophoblasts and in syncytialisation was investigated. Immunohistochemical stains of 13 PE and 13 control placentas were correlated, followed by cell culture experiments. An analysis of H3K4me<sup>3</sup> and H3K9ac was conducted, as well as cell fusion staining with E-cadherin and β-catenin-both after incubation with Gal-2. The expression of H3K4me<sup>3</sup> and H3K9ac correlated significantly with the expression of Gal-2. Furthermor","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-05T11:58:39.16Z","creation":"2025-04-05T11:58:39.16Z"},"accession":"S-EPMC9139023","cross_references":{"pubmed":["35625634"],"doi":["10.3390/biom12050707"]}}