biostudies-literatureUnknown11(10)Yang S<h4>Background</h4>Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.<h4>Methods</h4>A MI model of Kun-ming mice induced by left anterior descending coronary artery ligation was utilized to study the potential therapeutic effects of calcitriol on MI. AC16 human cardiomyocyte-like cells treated with TNF-α were used for exploring the mechanisms that underlie the cardioprotective effects of calcitriol.<h4>Results</h4>We observed that calcitriol reversed adverse cardiovascular function and cardiac remodeling in post-MI mice. Mechanistically, calcitriol suppressed MI-induced cardiac inflammation, ameliorated cardiomyocCells1676https://www.ebi.ac.uk/biostudies/studies/S-EPMC9139780biostudies-literatureNovel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.PMC9139780Chang NWang CChen MZhu FXiao QLiu XSheng LZhao PRuan CXu TYang SCao RGao SfalseNovel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction.<h4>Background</h4>Increasing evidence indicates that vitamin D deficiency negatively affects the cardiovascular system. Here we studied the therapeutic effects of calcitriol in myocardial infarction (MI) and investigated its underlying mechanisms.<h4>Methods</h4>A MI model of Kun-ming mice induced by left anterior descending coronary artery ligation was utilized to study the potential therapeutic effects of calcitriol on MI. AC16 human cardiomyocyte-like cells treated with TNF-α were used for exploring the mechanisms that underlie the cardioprotective effects of calcitriol.<h4>Results</h4>We observed that calcitriol reversed adverse cardiovascular function and cardiac remodeling in post-MI mice. Mechanistically, calcitriol suppressed MI-induced cardiac inflammation, ameliorated cardiomyoc2022-01-01T00:00:00Z2022 May2025-04-18T22:59:40.917Z2025-04-07T10:40:45.582ZS-EPMC91397803562671310.3390/cells11101676