{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peskar D"],"funding":["Slovenian Research Agency"],"pagination":["1078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9140099"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains poorly understood, as well as its effective diagnosis and therapy. Studying changes in tissue glycosylation patterns under pathological conditions is a promising way of discovering novel biomarkers and therapeutic targets. The glycobiology of IC/BPS is largely understudied, therefore we compared glycosylation patterns of normal human urothelium with the urothelium of IC/BPS patients using a selection of 10 plant-based lectins with different monosaccharide preferences. We also compared lectin binding to human urothelium with the two most cited experimental models of IC/BPS, specifically, TNFα-treated human urothelial cell line RT4 and cyclophosphamide-induced chronic cystitis in C57BL6/J mice. Furthermore, bindi"],"journal":["Diagnostics (Basel, Switzerland)"],"pubmed_title":["Lectins as Biomarkers of IC/BPS Disease: A Comparative Study of Glycosylation Patterns in Human Pathologic Urothelium and IC/BPS Experimental Models."],"pmcid":["PMC9140099"],"funding_grant_id":["P3-0108, J3-2521"],"pubmed_authors":["Peskar D","Erman A","Kuret T","Jeruc J"],"additional_accession":[]},"is_claimable":false,"name":"Lectins as Biomarkers of IC/BPS Disease: A Comparative Study of Glycosylation Patterns in Human Pathologic Urothelium and IC/BPS Experimental Models.","description":"Pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) remains poorly understood, as well as its effective diagnosis and therapy. Studying changes in tissue glycosylation patterns under pathological conditions is a promising way of discovering novel biomarkers and therapeutic targets. The glycobiology of IC/BPS is largely understudied, therefore we compared glycosylation patterns of normal human urothelium with the urothelium of IC/BPS patients using a selection of 10 plant-based lectins with different monosaccharide preferences. We also compared lectin binding to human urothelium with the two most cited experimental models of IC/BPS, specifically, TNFα-treated human urothelial cell line RT4 and cyclophosphamide-induced chronic cystitis in C57BL6/J mice. Furthermore, bindi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T13:29:43.1Z","creation":"2024-11-20T02:09:44.21Z"},"accession":"S-EPMC9140099","cross_references":{"pubmed":["35626233"],"doi":["10.3390/diagnostics12051078"]}}