{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vlasceanu GM"],"funding":["National Authority for Scientific Research and Innovation"],"pagination":["5336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9140409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["We designed graphene oxide composites with increased morphological and structural variability using fatty acid-coupled polysaccharide co-polymer as the continuous phase. The matrix was synthesized by N, O-acylation of chitosan with palmitic and lauric acid. The obtained co-polymer was crosslinked with genipin and composited with graphene oxide. FTIR spectra highlighted the modification and multi-components interaction. DLS, SEM, and contact angle tests demonstrated that the conjugation of hydrophobic molecules to chitosan increased surface roughness and hydrophilicity, since it triggered a core-shell macromolecular structuration. Nanoindentation revealed a notable durotaxis gradient due to chitosan/fatty acid self-organization and graphene sheet embedment. The composited building blocks wi"],"journal":["International journal of molecular sciences"],"pubmed_title":["Chitosan-Based Materials Featuring Multiscale Anisotropy for Wider Tissue Engineering Applications."],"pmcid":["PMC9140409"],"funding_grant_id":["154/2016"],"pubmed_authors":["Popescu CC","Ionescu I","Boerasu I","Giol ED","Dumitrascu AM","Vlasceanu GM","Ionita M","Floarea M","Olaret E","Iovu H","Ghitman J","Necolau MI"],"additional_accession":[]},"is_claimable":false,"name":"Chitosan-Based Materials Featuring Multiscale Anisotropy for Wider Tissue Engineering Applications.","description":"We designed graphene oxide composites with increased morphological and structural variability using fatty acid-coupled polysaccharide co-polymer as the continuous phase. The matrix was synthesized by N, O-acylation of chitosan with palmitic and lauric acid. The obtained co-polymer was crosslinked with genipin and composited with graphene oxide. FTIR spectra highlighted the modification and multi-components interaction. DLS, SEM, and contact angle tests demonstrated that the conjugation of hydrophobic molecules to chitosan increased surface roughness and hydrophilicity, since it triggered a core-shell macromolecular structuration. Nanoindentation revealed a notable durotaxis gradient due to chitosan/fatty acid self-organization and graphene sheet embedment. The composited building blocks wi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-29T14:36:29.45Z","creation":"2025-02-19T02:16:24.131Z"},"accession":"S-EPMC9140409","cross_references":{"pubmed":["35628150"],"doi":["10.3390/ijms23105336"]}}