biostudies-literatureUnknown12(5)Emdina ABiomarkers are increasingly recognized as tools in the diagnosis and prognosis of neurodegenerative diseases. No fluid biomarker for Parkinson's disease (PD) has been established to date, but α-synuclein, a major component of Lewy bodies in PD and dementia with Lewy bodies (DLB), has become a promising candidate. Here, we investigated CSF α-synuclein in patients with PD (<i>n</i> = 28), PDD (<i>n</i> = 8), and DLB (<i>n</i> = 5), applying an electrochemiluminescence immunoassay. Median values were non-significantly (<i>p</i> = 0.430) higher in patients with PDD and DLB (287 pg/mL) than in PD (236 pg/mL). A group of <i>n</i> = 36 primarily non-demented patients with PD and PDD was clinically followed for up to two years. A higher baseline α-synuclein was associated with increases in Hoehn aDiagnostics (Basel, Switzerland)1259https://www.ebi.ac.uk/biostudies/studies/S-EPMC9140902biostudies-literatureBaseline Cerebrospinal Fluid α-Synuclein in Parkinson's Disease Is Associated with Disease Progression and Cognitive Decline.PMC9140902Maass FLlorens FBunck TGoebel SKruse NZerr ISchmitz MLingor PMollenhauer BVarges DEmdina ANuhn SHermann PfalseBaseline Cerebrospinal Fluid α-Synuclein in Parkinson's Disease Is Associated with Disease Progression and Cognitive Decline.Biomarkers are increasingly recognized as tools in the diagnosis and prognosis of neurodegenerative diseases. No fluid biomarker for Parkinson's disease (PD) has been established to date, but α-synuclein, a major component of Lewy bodies in PD and dementia with Lewy bodies (DLB), has become a promising candidate. Here, we investigated CSF α-synuclein in patients with PD (<i>n</i> = 28), PDD (<i>n</i> = 8), and DLB (<i>n</i> = 5), applying an electrochemiluminescence immunoassay. Median values were non-significantly (<i>p</i> = 0.430) higher in patients with PDD and DLB (287 pg/mL) than in PD (236 pg/mL). A group of <i>n</i> = 36 primarily non-demented patients with PD and PDD was clinically followed for up to two years. A higher baseline α-synuclein was associated with increases in Hoehn a2022-01-01T00:00:00Z2022 May2025-04-26T02:46:19.524Z2025-02-19T02:16:27.333ZS-EPMC91409023562641510.3390/diagnostics12051259