biostudies-literatureUnknown13(5)Liao JCircular RNA (CircRNA) is related to tumor development. Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of non-small-cell lung cancer (NSCLC) were un-explored. The correlations of expression levels of hsa_circ_0006692 in NSCLC specimens and cells with pathological characteristics were studied. The interactions of hsa_circ_0006692 with miR-205-5p and CDK19 were assessed with real-time PCR, RNA-binding protein immunoprecipitation (RIP), luciferase reporter, RNA pull-down, and fluorescence in situ hybridization (FISH). The roles of hsa_circ_0006692 on cell growth, invasion, and migration in vitro and metastasis in vivo were evaluated. Hsa_circ_0006692 was over-expressed in 60 cases of NSCLC specimensGenes846https://www.ebi.ac.uk/biostudies/studies/S-EPMC9141027biostudies-literatureHsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis.PMC9141027Liao JHuang TChen ZLin GLin XZheng QLuo XZhang LSu YXu HLin KfalseHsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis.Circular RNA (CircRNA) is related to tumor development. Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of non-small-cell lung cancer (NSCLC) were un-explored. The correlations of expression levels of hsa_circ_0006692 in NSCLC specimens and cells with pathological characteristics were studied. The interactions of hsa_circ_0006692 with miR-205-5p and CDK19 were assessed with real-time PCR, RNA-binding protein immunoprecipitation (RIP), luciferase reporter, RNA pull-down, and fluorescence in situ hybridization (FISH). The roles of hsa_circ_0006692 on cell growth, invasion, and migration in vitro and metastasis in vivo were evaluated. Hsa_circ_0006692 was over-expressed in 60 cases of NSCLC specimens2022-01-01T00:00:00Z2022 May2025-04-19T17:39:09.219Z2025-02-19T04:30:48.512ZS-EPMC91410273562723210.3390/genes13050846