{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cruz FA"],"funding":["University of California, Irvine","National Institute of General Medical Sciences","Eli Lilly and Company","NIGMS NIH HHS","National Science Foundation"],"pagination":["1029-1032"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9141309"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["139(3)"],"pubmed_abstract":["We report an enantioselective coupling between α-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine."],"pmcid":["PMC9141309"],"funding_grant_id":["GM105938","R01 GM105938"],"pubmed_authors":["Cruz FA","Dong VM"],"additional_accession":[]},"is_claimable":false,"name":"Stereodivergent Coupling of Aldehydes and Alkynes via Synergistic Catalysis Using Rh and Jacobsen's Amine.","description":"We report an enantioselective coupling between α-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2024-11-15T16:23:36.48Z","creation":"2024-11-15T16:23:36.48Z"},"accession":"S-EPMC9141309","cross_references":{"pubmed":["28074655"],"doi":["10.1021/jacs.6b10680"]}}