{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li WF"],"funding":["Research Grants Council of the Hong Kong Special Administrative Region, China","National Key R&amp;D Program of China","Tip-top Talent Foundation of Department of Education","National Natural Science Foundation of China","Hong Kong Baptist University, Research Committee, and University Grants Committee of the Hong Kong Special Administrative Region, China"],"pagination":["3098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9143206"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(10)"],"pubmed_abstract":["Three isopimarane diterpenes [fladins B (<b>1</b>), C (<b>2</b>), and D (<b>3</b>)] were isolated from the twigs and leaves of Chinese folk medicine, <i>Isodon flavidus</i>. The chemical structures were determined by the analysis of the comprehensive spectroscopic data, and the absolute configuration was confirmed by X-ray crystallographic analysis. The structures of <b>1</b>-<b>3</b> were formed from isopimaranes through the rearrangement of ring A by the bond break at C-3 and C-4 to form a new <i>δ</i>-lactone ring system between C-3 and C-9. This structure type represents the first discovery of a natural isopimarane diterpene with an unusual lactone moiety at C-9 and C-10. In the crystal of <b>1</b>, molecules are linked to each other by intermolecular O-H···O bonds, forming chains alon"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["3,4-<i>Seco</i>-Isopimarane Diterpenes from the Twigs and Leaves of <i>Isodon Flavidus</i>."],"pmcid":["PMC9143206"],"funding_grant_id":["KY (2021)034","(UGC Research Matching Grant Scheme RMGS2019_1_19","81760772","13103917","2019YFC1712500"],"pubmed_authors":["Tsang NY","Zou J","Zhang HJ","Pan LT","Liu YH","He K","Li WF","Liang ZM","Li JX","Zhao CL","Rong L"],"additional_accession":[]},"is_claimable":false,"name":"3,4-<i>Seco</i>-Isopimarane Diterpenes from the Twigs and Leaves of <i>Isodon Flavidus</i>.","description":"Three isopimarane diterpenes [fladins B (<b>1</b>), C (<b>2</b>), and D (<b>3</b>)] were isolated from the twigs and leaves of Chinese folk medicine, <i>Isodon flavidus</i>. The chemical structures were determined by the analysis of the comprehensive spectroscopic data, and the absolute configuration was confirmed by X-ray crystallographic analysis. The structures of <b>1</b>-<b>3</b> were formed from isopimaranes through the rearrangement of ring A by the bond break at C-3 and C-4 to form a new <i>δ</i>-lactone ring system between C-3 and C-9. This structure type represents the first discovery of a natural isopimarane diterpene with an unusual lactone moiety at C-9 and C-10. In the crystal of <b>1</b>, molecules are linked to each other by intermolecular O-H···O bonds, forming chains alon","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T01:19:57.117Z","creation":"2025-02-19T04:31:02.094Z"},"accession":"S-EPMC9143206","cross_references":{"pubmed":["35630575"],"doi":["10.3390/molecules27103098"]}}