biostudies-literatureMacchiaverni PUniversity of Western Australiathe Netherlands Ministry of Health, Welfare, and Sportthe Netherlands Ministry of Spatial Planning, Housing, and the Environmentthe Netherlands Asthma FundUniversité de Nice Sophia-Antipolis (UNS)the Netherlands Organization for Scientific ResearchInstitut National de la Santé et Recherche Médicale (INSERM)CSRD VA2095https://www.ebi.ac.uk/biostudies/studies/S-EPMC9143372biostudies-literatureUnknown14(10)Allergies are major noncommunicable diseases associated with significant morbidity, reduced quality of life, and high healthcare costs. Despite decades of research, it is still unknown if early-life exposure to indoor allergens plays a role in the development of IgE-mediated allergy and asthma. The objective of this study is to contribute to the identification of early-life risk factors for developing allergy. We addressed whether two different sources of house dust mite <i>Der p</i> 1 allergen exposure during early life, i.e., human milk and dust, have different relationships with IgE levels and asthma outcomes in children. We performed longitudinal analyses in 249 mother-child pairs using data from the PIAMA birth cohort. Asthma symptoms and serum total and specific IgE levels in childreNutrientsHouse Dust Mite Exposure through Human Milk and Dust: What Matters for Child Allergy Risk?PMC914337212345678Rekima AVerhasselt VGehring UMacchiaverni PWijga AHfalseHouse Dust Mite Exposure through Human Milk and Dust: What Matters for Child Allergy Risk?Allergies are major noncommunicable diseases associated with significant morbidity, reduced quality of life, and high healthcare costs. Despite decades of research, it is still unknown if early-life exposure to indoor allergens plays a role in the development of IgE-mediated allergy and asthma. The objective of this study is to contribute to the identification of early-life risk factors for developing allergy. We addressed whether two different sources of house dust mite <i>Der p</i> 1 allergen exposure during early life, i.e., human milk and dust, have different relationships with IgE levels and asthma outcomes in children. We performed longitudinal analyses in 249 mother-child pairs using data from the PIAMA birth cohort. Asthma symptoms and serum total and specific IgE levels in childre2022-01-01T00:00:00Z2022 May2025-04-05T11:12:52Z2025-02-19T03:22:31.17ZS-EPMC91433723563123610.3390/nu14102095