biostudies-literatureChang KCChina Medical University hospitalTaiwan Ministry of Science and TechnologyChina Medical University Hospital835https://www.ebi.ac.uk/biostudies/studies/S-EPMC9143734biostudies-literatureUnknown12(5)Background: The effects of methadone-induced severe prolongation of the corrected QT interval (QTc) and sudden cardiac death appear unpredictable and sex-dependent. Genetic polymorphisms in the nitric oxide synthase 1 adaptor protein (NOS1AP) have been implicated in QTc prolongation in general populations. We investigated whether common NOS1AP variants interact with methadone in relation to QTc prolongation in patients with heroin dependence. Methods: We genotyped 17 NOS1AP variants spanning the entire gene in heroin-dependent patients who received a 12-lead electrocardiography (ECG) examination both at baseline and during maintenance methadone treatment in Cohort 1 and only during maintenance methadone treatment in Cohort 2. The QT interval was measured automatically by the Marquette 12SLJournal of personalized medicineAssociation of a Common <i>NOS1AP</i> Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment.PMC9143734DMR-111-020MOST 110-2314-B-039-050 and MOST 109-2314-B-039-045DMR-111-020 and DMR-110-012MOST 109-2314-B-039-045MOST 110-2314-B-039-050DMR-110-012Wu MYChung WHChen KWChang KCShiao YTLane HYLiao WLLin YKHuang CLLin YNfalseAssociation of a Common <i>NOS1AP</i> Variant with Attenuation of QTc Prolongation in Men with Heroin Dependence Undergoing Methadone Treatment.Background: The effects of methadone-induced severe prolongation of the corrected QT interval (QTc) and sudden cardiac death appear unpredictable and sex-dependent. Genetic polymorphisms in the nitric oxide synthase 1 adaptor protein (NOS1AP) have been implicated in QTc prolongation in general populations. We investigated whether common NOS1AP variants interact with methadone in relation to QTc prolongation in patients with heroin dependence. Methods: We genotyped 17 NOS1AP variants spanning the entire gene in heroin-dependent patients who received a 12-lead electrocardiography (ECG) examination both at baseline and during maintenance methadone treatment in Cohort 1 and only during maintenance methadone treatment in Cohort 2. The QT interval was measured automatically by the Marquette 12SL2022-01-01T00:00:00Z2022 May2026-05-07T03:16:46.597Z2025-02-19T02:58:39.48ZS-EPMC91437343562925710.3390/jpm12050835