{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Katsouda A"],"funding":["Hellenic Institute for the Study of Sepsis","Swiss National Science Foundation","British Heart Foundation","Deutsche Forschungsgemeinschaft","Hellenic Foundation for Research and Innovation","Cardio-Pulmonary Institute","Hellenic State Scholarship Foundation IKY-Siemens Research Projects of Excellence","European Regional Development Fund"],"pagination":["e20211894"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9143789"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["219(7)"],"pubmed_abstract":["Given the clinical, economic, and societal impact of obesity, unraveling the mechanisms of adipose tissue expansion remains of fundamental significance. We previously showed that white adipose tissue (WAT) levels of 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme that yields pyruvate and sulfide species, are downregulated in obesity. Here, we report that Mpst deletion results in fat accumulation in mice fed a high-fat diet (HFD) through transcriptional and metabolic maladaptation. Mpst-deficient mice on HFD exhibit increased body weight and inguinal WAT mass, reduced metabolic rate, and impaired glucose/insulin tolerance. At the molecular level, Mpst ablation activates HIF1α, downregulates subunits of the translocase of outer/inner membrane (TIM/TO"],"journal":["The Journal of experimental medicine"],"pubmed_title":["MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity."],"pmcid":["PMC9143789"],"funding_grant_id":["11/3056","EXC 2026","CRC1366/1","TG/19/2/34831","CH/F/21/90009","31003A_179434","179434","RG/F/21/110040"],"pubmed_authors":["Zuhra K","Havaki S","Papapetropoulos A","Bibli SI","Akoumianakis I","Katsouda A","Nagahara N","Dionellis VS","Antoniades C","Gorgoulis VG","Karaliota S","Szabo C","Thanos D","Fleming I","Valakos D"],"additional_accession":[]},"is_claimable":false,"name":"MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity.","description":"Given the clinical, economic, and societal impact of obesity, unraveling the mechanisms of adipose tissue expansion remains of fundamental significance. We previously showed that white adipose tissue (WAT) levels of 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme that yields pyruvate and sulfide species, are downregulated in obesity. Here, we report that Mpst deletion results in fat accumulation in mice fed a high-fat diet (HFD) through transcriptional and metabolic maladaptation. Mpst-deficient mice on HFD exhibit increased body weight and inguinal WAT mass, reduced metabolic rate, and impaired glucose/insulin tolerance. At the molecular level, Mpst ablation activates HIF1α, downregulates subunits of the translocase of outer/inner membrane (TIM/TO","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-09T16:21:19.538Z","creation":"2025-02-19T03:23:34.828Z"},"accession":"S-EPMC9143789","cross_references":{"pubmed":["35616614"],"doi":["10.1084/jem.20211894"]}}