{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dozier C"],"funding":["Fondation ARC pour la Recherche sur le Cancer","Agence Nationale de la Recherche"],"pagination":["5764"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9144653"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). However, several lnc pri-miRNAs contain translatable small open reading frames (smORFs). If smORFs present within lncRNAs can encode functional small peptides, they can also constitute <i>cis</i>-regulatory elements involved in lncRNA decay. Here, we investigated the possible involvement of smORFs in the regulation of lnc pri-miRNAs in <i>Human</i> and <i>Drosophila</i>, focusing on pri-miR"],"journal":["International journal of molecular sciences"],"pubmed_title":["Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in <i>Human</i> and <i>Drosophila</i>."],"pmcid":["PMC9144653"],"funding_grant_id":["ANR biomiPEPs ANR-16-CE12-0018","ARC PGA1 RF20180206987"],"pubmed_authors":["Dozier C","Montigny A","Plaza S","Combier JP","Viladrich M","Culerrier R","Besson A"],"additional_accession":[]},"is_claimable":false,"name":"Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in <i>Human</i> and <i>Drosophila</i>.","description":"MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). However, several lnc pri-miRNAs contain translatable small open reading frames (smORFs). If smORFs present within lncRNAs can encode functional small peptides, they can also constitute <i>cis</i>-regulatory elements involved in lncRNA decay. Here, we investigated the possible involvement of smORFs in the regulation of lnc pri-miRNAs in <i>Human</i> and <i>Drosophila</i>, focusing on pri-miR","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T18:22:13.44Z","creation":"2025-04-06T02:23:03.989Z"},"accession":"S-EPMC9144653","cross_references":{"pubmed":["35628573"],"doi":["10.3390/ijms23105764"]}}