biostudies-literatureChoi NRBasic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education1348https://www.ebi.ac.uk/biostudies/studies/S-EPMC9145079biostudies-literatureUnknown11(10)<i>Pinellia ternata Breitenbach</i> (PTB) is a widely used herbal medicine in China, Japan, and South Korea. It has antiemetic, anti-inflammatory, antitussive, and sedative properties. The raw material is toxic, but can be made safer using alum solution or by boiling it for a long time. In addition, PTB seems to be effective for gastrointestinal motility disorders (GMDs), but this is yet to be conclusively proven. Herein, PTB compounds, targets, and related diseases were investigated using the traditional Chinese medical systems pharmacology database and an analysis platform. Information on target genes was confirmed using the UniProt database. Using Cytoscape 3.8.2, a network was established and GMD-related genes were searched using the Cytoscape stringApp. The effects of the PTB extract Plants (Basel, Switzerland)Prediction of the Medicinal Mechanisms of <i>Pinellia ternata Breitenbach</i>, a Traditional Medicine for Gastrointestinal Motility Disorders, through Network Pharmacology.PMC91450792021R1I1A3042479Choi NRKo SJKim JNPark JWPark JChoi WKim BJfalsePrediction of the Medicinal Mechanisms of <i>Pinellia ternata Breitenbach</i>, a Traditional Medicine for Gastrointestinal Motility Disorders, through Network Pharmacology.<i>Pinellia ternata Breitenbach</i> (PTB) is a widely used herbal medicine in China, Japan, and South Korea. It has antiemetic, anti-inflammatory, antitussive, and sedative properties. The raw material is toxic, but can be made safer using alum solution or by boiling it for a long time. In addition, PTB seems to be effective for gastrointestinal motility disorders (GMDs), but this is yet to be conclusively proven. Herein, PTB compounds, targets, and related diseases were investigated using the traditional Chinese medical systems pharmacology database and an analysis platform. Information on target genes was confirmed using the UniProt database. Using Cytoscape 3.8.2, a network was established and GMD-related genes were searched using the Cytoscape stringApp. The effects of the PTB extract 2022-01-01T00:00:00Z2022 May2025-04-18T23:02:43.306Z2024-11-13T16:05:49.899ZS-EPMC91450793563177310.3390/plants11101348