{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mizutani A"],"funding":["Shin Nippon Biomedical Laboratories, Ltd.","Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science"],"pagination":["1026"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9145277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was examined using domperidone, a dopamine D2 receptor ligand, as the model drug, with intranasal administration at 0, 15, or 30 min before intravenous [<sup>123</sup>I]IBZM administration. In the striatum, [<sup>123</sup>I]IBZM accumulation was significantly lower after intranasal (IN) domperidone administration than in controls 15 min after intravenous [<sup>125</sup>I]IBZM administration. [<sup>123</sup>I]IBZM SPECT was acquired with intravenous (IV) or IN domperidone administration 15 min before ["],"journal":["Pharmaceutics"],"pubmed_title":["Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood-Brain Barrier Permeability in Mice."],"pmcid":["PMC9145277"],"funding_grant_id":["01","18K19508 and 21H02865"],"pubmed_authors":["Nishii R","Kawai K","Sasaki K","Torikai Y","Fukakusa S","Suzuki C","Magata Y","Muranaka Y","Ohuchi M","Kobayashi M","Haruta S","Mizutani A"],"additional_accession":[]},"is_claimable":false,"name":"Indirect SPECT Imaging Evaluation for Possible Nose-to-Brain Drug Delivery Using a Compound with Poor Blood-Brain Barrier Permeability in Mice.","description":"Single-photon emission computed tomography (SPECT) imaging using intravenous radioactive ligand administration to indirectly evaluate the time-dependent effect of intranasal drugs with poor blood-brain barrier permeability on brain drug distributions in mice was evaluated. The biodistribution was examined using domperidone, a dopamine D2 receptor ligand, as the model drug, with intranasal administration at 0, 15, or 30 min before intravenous [<sup>123</sup>I]IBZM administration. In the striatum, [<sup>123</sup>I]IBZM accumulation was significantly lower after intranasal (IN) domperidone administration than in controls 15 min after intravenous [<sup>125</sup>I]IBZM administration. [<sup>123</sup>I]IBZM SPECT was acquired with intravenous (IV) or IN domperidone administration 15 min before [","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T18:21:51.093Z","creation":"2025-04-06T02:22:58.043Z"},"accession":"S-EPMC9145277","cross_references":{"pubmed":["35631611"],"doi":["10.3390/pharmaceutics14051026"]}}