biostudies-literatureCheng SNatural Science Foundation of ChinaDOST-Philippines and MOST-China joint R&D projectMacedonian-Chinese Scientific and Technological Cooperation projectNatural Science Foundation of Jilin Province911https://www.ebi.ac.uk/biostudies/studies/S-EPMC9145607biostudies-literatureUnknown14(5)The highly virulent Newcastle disease virus (NDV) isolates typically result in severe systemic pathological changes and high mortality in Newcastle disease (ND) illness, whereas avirulent or low-virulence NDV strains can cause subclinical disease with no morbidity and even asymptomatic infections in birds. However, understanding the host's innate immune responses to infection with either a highly virulent strain or an avirulent strain, and how this response may contribute to severe pathological damages and even mortality upon infection with the highly virulent strain, remain limited. Therefore, the differences in epigenetic and pathogenesis mechanisms between the highly virulent and avirulent strains were explored, by transcriptional profiling of chicken embryonic visceral tissues (CEVT), VirusesIntense Innate Immune Responses and Severe Metabolic Disorders in Chicken Embryonic Visceral Tissues Caused by Infection with Highly Virulent Newcastle Disease Virus Compared to the Avirulent Virus: A Bioinformatics Analysis.PMC91456076–19; 20-6337/1319023012021YFE010910020190301087NYSha YRen YYin RDodovski AJiang SYan WChai HGao CAlfonso PCheng SLiu XWang MStoeger TMu JWang SMingala CNDing ZTseren-Ochir EOfalseIntense Innate Immune Responses and Severe Metabolic Disorders in Chicken Embryonic Visceral Tissues Caused by Infection with Highly Virulent Newcastle Disease Virus Compared to the Avirulent Virus: A Bioinformatics Analysis.The highly virulent Newcastle disease virus (NDV) isolates typically result in severe systemic pathological changes and high mortality in Newcastle disease (ND) illness, whereas avirulent or low-virulence NDV strains can cause subclinical disease with no morbidity and even asymptomatic infections in birds. However, understanding the host's innate immune responses to infection with either a highly virulent strain or an avirulent strain, and how this response may contribute to severe pathological damages and even mortality upon infection with the highly virulent strain, remain limited. Therefore, the differences in epigenetic and pathogenesis mechanisms between the highly virulent and avirulent strains were explored, by transcriptional profiling of chicken embryonic visceral tissues (CEVT), 2022-01-01T00:00:00Z2022 Apr2026-04-08T10:01:02.94Z2024-11-05T20:38:05.247ZS-EPMC91456073563265110.3390/v14050911