{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang C"],"funding":["the Modern Dental Laboratory/HKU Endowment Fund to L.J. Jin","the Hong Kong Research Grants Council"],"pagination":["5728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9146424"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(10)"],"pubmed_abstract":["<i>Porphyromonas gingivalis</i> as the keystone periodontopathogen plays a critical role in the pathogenesis of periodontitis, and crucially accounts for inflammatory comorbidities such as cardiovascular disease and Alzheimer's disease. We recently identified the existence of <i>P. gingivalis</i> persisters and revealed the unforeseen perturbation of innate response in human gingival epithelial cells (HGECs) due to these noxious persisters. Herein, RNA sequencing revealed how <i>P. gingivalis</i> persisters affected the expression profile of cytokine genes and related signaling pathways in HGECs. Results showed that metronidazole-treated <i>P. gingivalis</i> persisters (M-PgPs) impaired the innate host defense of HGECs, in a similar fashion to <i>P. gingivalis</i>. Notably, over one thousa"],"journal":["International journal of molecular sciences"],"pubmed_title":["RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in <i>Porphyromonas gingivalis</i> Persister-Treated Human Gingival Epithelial Cells."],"pmcid":["PMC9146424"],"funding_grant_id":["Nil","17122918, 17119819"],"pubmed_authors":["Li X","Cheng T","Wang C","Wang L","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"RNA Sequencing Reveals the Upregulation of FOXO Signaling Pathway in <i>Porphyromonas gingivalis</i> Persister-Treated Human Gingival Epithelial Cells.","description":"<i>Porphyromonas gingivalis</i> as the keystone periodontopathogen plays a critical role in the pathogenesis of periodontitis, and crucially accounts for inflammatory comorbidities such as cardiovascular disease and Alzheimer's disease. We recently identified the existence of <i>P. gingivalis</i> persisters and revealed the unforeseen perturbation of innate response in human gingival epithelial cells (HGECs) due to these noxious persisters. Herein, RNA sequencing revealed how <i>P. gingivalis</i> persisters affected the expression profile of cytokine genes and related signaling pathways in HGECs. Results showed that metronidazole-treated <i>P. gingivalis</i> persisters (M-PgPs) impaired the innate host defense of HGECs, in a similar fashion to <i>P. gingivalis</i>. Notably, over one thousa","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-29T14:36:24.83Z","creation":"2025-02-19T02:16:20.636Z"},"accession":"S-EPMC9146424","cross_references":{"pubmed":["35628542"],"doi":["10.3390/ijms23105728"]}}