{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ribeiro DL"],"funding":["Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer)","São Paulo Research Foundation","FAPESP","State University of Londrina (UEL)","Coordination for the Improvement of Higher Education Personnel","Coordenação de Aperfeicoamento de Pessoal de Nível Superior","University of São Paulo (USP)","Maranhão Foundation for Research and Scientific and Technological Development","National Council for Scientific and Technological Development","Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão"],"pagination":["963"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9147598"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents. Brachydin A (BrA), a glycosylated flavonoid extracted from <i>Fridericia platyphylla</i>, displays a remarkable antitumoral effect against in vitro mPCa cells cultured as bidimensional (2D) monolayers. Considering that three-dimensional (3D) cell cultures provide a more accurate response to chemotherapeutic agents, this study investigated the antiproliferative/antimetastatic effects of BrA and the molecular mechanisms underlying its action in mPCa spheroids (DU145) in vitro. BrA at 60-100 μM was cytotoxic, altered spheroid morphology/volume, and suppressed cell migration and tumor invasiveness. High-content analysis revealed that BrA (60-100 µM) reduced mitochondrial membrane potential and increased apoptosi"],"journal":["Pharmaceutics"],"pubmed_title":["The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death."],"pmcid":["PMC9147598"],"funding_grant_id":["# 00849/18","Research Productivity grant # 308231/2017","# 2017/22305-9","National Postdoctoral Program PNPD grant # 88887.354023/2019 and Finance Code 001","Postdoctoral Fellowship grant #151520/2018-6 and Universal Project grant # 426246/2018-7","grant # 00849/18","Postdoctoral Fellowship grant #151520/2018-6","Universal Project grant # 426246/2018-7"],"pubmed_authors":["Rocha CQD","Antunes LMG","Tuttis K","Oliveira LCB","Gomes INF","Lengert AVH","Serpeloni JM","Ribeiro DL","Reis RM","Colus IMS"],"additional_accession":[]},"is_claimable":false,"name":"The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death.","description":"Metastatic prostate cancer (mPCa) is resistant to several chemotherapeutic agents. Brachydin A (BrA), a glycosylated flavonoid extracted from <i>Fridericia platyphylla</i>, displays a remarkable antitumoral effect against in vitro mPCa cells cultured as bidimensional (2D) monolayers. Considering that three-dimensional (3D) cell cultures provide a more accurate response to chemotherapeutic agents, this study investigated the antiproliferative/antimetastatic effects of BrA and the molecular mechanisms underlying its action in mPCa spheroids (DU145) in vitro. BrA at 60-100 μM was cytotoxic, altered spheroid morphology/volume, and suppressed cell migration and tumor invasiveness. High-content analysis revealed that BrA (60-100 µM) reduced mitochondrial membrane potential and increased apoptosi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-21T03:16:37.653Z","creation":"2024-11-05T20:39:15.775Z"},"accession":"S-EPMC9147598","cross_references":{"pubmed":["35631550"],"doi":["10.3390/pharmaceutics14050963"]}}