{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nakano T"],"funding":["AMED, Practical Research Project for Rare/Intractable Diseases","MEXT KAKENHI, Grants-in-aid from the Ministry of Education, Culture, Sports, Science","AMED, Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus","Health Labour Sciences Research, Technology and the Ministry of Health, Labor, and Welfare of Japan","AMED, Platform Program for Promotion of Genome Medicine"],"pagination":["792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9147607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["<h4>Background</h4>Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients.<h4>Methods</h4>We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples.<h4>Results</h4>The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiom"],"journal":["Journal of personalized medicine"],"pubmed_title":["Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function."],"pmcid":["PMC9147607"],"funding_grant_id":["JP19km0405009","JP19ek0109367, JP19ek0109406","JP19ek0210080, JP19ek0210118, JP19ek0210121, JP19ek0210115","19189094, 17933459","JP19155855"],"pubmed_authors":["Hoshii Y","Terada C","Saito Y","Nakano T","Nakada Y","Ueda T","Hatakeyama K","Hashimoto Y","Nakagawa H","Seno A","Watanabe M","Sakaguchi Y","Nishida T","Ohbayashi C","Ishihara S","Terasaki S","Onoue K"],"additional_accession":[]},"is_claimable":false,"name":"Transthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function.","description":"<h4>Background</h4>Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients.<h4>Methods</h4>We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples.<h4>Results</h4>The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiom","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-29T14:36:21.096Z","creation":"2025-02-19T02:16:19.215Z"},"accession":"S-EPMC9147607","cross_references":{"pubmed":["35629214"],"doi":["10.3390/jpm12050792"]}}