biostudies-literatureNakano TAMED, Practical Research Project for Rare/Intractable DiseasesMEXT KAKENHI, Grants-in-aid from the Ministry of Education, Culture, Sports, ScienceAMED, Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes MellitusHealth Labour Sciences Research, Technology and the Ministry of Health, Labor, and Welfare of JapanAMED, Platform Program for Promotion of Genome Medicine792https://www.ebi.ac.uk/biostudies/studies/S-EPMC9147607biostudies-literatureUnknown12(5)<h4>Background</h4>Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients.<h4>Methods</h4>We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples.<h4>Results</h4>The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiomJournal of personalized medicineTransthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function.PMC9147607JP19km0405009JP19ek0109367, JP19ek0109406JP19ek0210080, JP19ek0210118, JP19ek0210121, JP19ek021011519189094, 17933459JP19155855Hoshii YTerada CSaito YNakano TNakada YUeda THatakeyama KHashimoto YNakagawa HSeno AWatanabe MSakaguchi YNishida TOhbayashi CIshihara STerasaki SOnoue KfalseTransthyretin Amyloid Cardiomyopathy: Impact of Transthyretin Amyloid Deposition in Myocardium on Cardiac Morphology and Function.<h4>Background</h4>Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is increasingly being recognized as a cause of left ventricular (LV) hypertrophy (LVH) and progressive heart failure in elderly patients. However, little is known about the cardiac morphology of ATTR-CM and the association between the degree of TTR amyloid deposition and cardiac dysfunction in these patients.<h4>Methods</h4>We studied 28 consecutive patients with ATTR-CM and analyzed the relationship between echocardiographic parameters and pathological features using endomyocardial biopsy samples.<h4>Results</h4>The cardiac geometries of patients with ATTR-CM were mainly classified as concentric LVH (96.4%). The relative wall thickness, a marker of LVH, tended to be positively correlated with the degree of non-cardiom2022-01-01T00:00:00Z2022 May2025-05-29T14:36:21.096Z2025-02-19T02:16:19.215ZS-EPMC91476073562921410.3390/jpm12050792