{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toledano M"],"funding":["Ministry of Economy, Industry and Competitiveness"],"pagination":["2078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9147672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(10)"],"pubmed_abstract":["Our objective is to evaluate the regional regenerative potential of calvarial bone in critical-sized defects in a rabbit model using novel nanostructured silica-loaded membranes doped with zinc or doxycycline. Nanostructured membranes of (MMA)<sub>1</sub>-co-(HEMA)<sub>1</sub>/(MA)<sub>3</sub>-co-(HEA)<sub>2</sub> loaded with 5 wt% of SiO<sub>2</sub> nanoparticles (HOOC-Si-Membranes) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were created on six New-Zealand-breed rabbit skulls and covered with the membranes. A sham defect without a membrane was used as the control. After six weeks, a histological analysis (toluidine blue technique) was employed to determine the area percentages of newly formed bone, osteoid bone, and soft tissue."],"journal":["Polymers"],"pubmed_title":["Histomorphometric Analysis of Differential Regional Bone Regeneration Induced by Distinct Doped Membranes."],"pmcid":["PMC9147672"],"funding_grant_id":["PID2020-114694RB-I00 MINECO/AEI/FEDER/UE"],"pubmed_authors":["Vallecillo C","Toledano M","Torres-Lagares D","Toledano-Osorio M","Serrera-Figallo MA","Gutierrez-Corrales A"],"additional_accession":[]},"is_claimable":false,"name":"Histomorphometric Analysis of Differential Regional Bone Regeneration Induced by Distinct Doped Membranes.","description":"Our objective is to evaluate the regional regenerative potential of calvarial bone in critical-sized defects in a rabbit model using novel nanostructured silica-loaded membranes doped with zinc or doxycycline. Nanostructured membranes of (MMA)<sub>1</sub>-co-(HEMA)<sub>1</sub>/(MA)<sub>3</sub>-co-(HEA)<sub>2</sub> loaded with 5 wt% of SiO<sub>2</sub> nanoparticles (HOOC-Si-Membranes) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were created on six New-Zealand-breed rabbit skulls and covered with the membranes. A sham defect without a membrane was used as the control. After six weeks, a histological analysis (toluidine blue technique) was employed to determine the area percentages of newly formed bone, osteoid bone, and soft tissue.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-05-29T14:36:25.499Z","creation":"2025-02-19T02:16:24.882Z"},"accession":"S-EPMC9147672","cross_references":{"pubmed":["35631960"],"doi":["10.3390/polym14102078"]}}