biostudies-literatureToledano MMinistry of Economy, Industry and Competitiveness2078https://www.ebi.ac.uk/biostudies/studies/S-EPMC9147672biostudies-literatureUnknown14(10)Our objective is to evaluate the regional regenerative potential of calvarial bone in critical-sized defects in a rabbit model using novel nanostructured silica-loaded membranes doped with zinc or doxycycline. Nanostructured membranes of (MMA)<sub>1</sub>-co-(HEMA)<sub>1</sub>/(MA)<sub>3</sub>-co-(HEA)<sub>2</sub> loaded with 5 wt% of SiO<sub>2</sub> nanoparticles (HOOC-Si-Membranes) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were created on six New-Zealand-breed rabbit skulls and covered with the membranes. A sham defect without a membrane was used as the control. After six weeks, a histological analysis (toluidine blue technique) was employed to determine the area percentages of newly formed bone, osteoid bone, and soft tissue.PolymersHistomorphometric Analysis of Differential Regional Bone Regeneration Induced by Distinct Doped Membranes.PMC9147672PID2020-114694RB-I00 MINECO/AEI/FEDER/UEVallecillo CToledano MTorres-Lagares DToledano-Osorio MSerrera-Figallo MAGutierrez-Corrales AfalseHistomorphometric Analysis of Differential Regional Bone Regeneration Induced by Distinct Doped Membranes.Our objective is to evaluate the regional regenerative potential of calvarial bone in critical-sized defects in a rabbit model using novel nanostructured silica-loaded membranes doped with zinc or doxycycline. Nanostructured membranes of (MMA)<sub>1</sub>-co-(HEMA)<sub>1</sub>/(MA)<sub>3</sub>-co-(HEA)<sub>2</sub> loaded with 5 wt% of SiO<sub>2</sub> nanoparticles (HOOC-Si-Membranes) were doped with zinc (Zn-HOOC-Si-Membrane) or doxycycline (Dox-HOOC-Si-Membrane). Critical bone defects were created on six New-Zealand-breed rabbit skulls and covered with the membranes. A sham defect without a membrane was used as the control. After six weeks, a histological analysis (toluidine blue technique) was employed to determine the area percentages of newly formed bone, osteoid bone, and soft tissue.2022-01-01T00:00:00Z2022 May2025-05-29T14:36:25.499Z2025-02-19T02:16:24.882ZS-EPMC91476723563196010.3390/polym14102078