{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(11)"],"submitter":["Bakhashab S"],"pubmed_abstract":["Polycystic ovary syndrome (PCOS) is characterised by infertility, obesity, insulin resistance and clinical and/or biochemical signs of hyperandrogenism. Obesity is known to be correlated with PCOS causing ovulatory dysfunction and hormone imbalances. Moreover, fat mass and the obesity gene (FTO) were linked with obesity and PCOS. Therefore, it is of interest to determine the genotype and allele frequency for three FTO variants - rs17817449 (G/T), rs1421085 (C/T) and rs8050136 (A/C) -in western Saudi population. 95 PCOS patients and 94 controls were recruited for this study. The genetic variants were assayed using real-time polymerase chain reaction using TaqMan genotyping assays. The chi-squared test was applied to investigate the difference between single nucleotide polymorphisms on PCOS "],"journal":["Bioinformation"],"pagination":["904-910"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9148595"],"repository":["biostudies-literature"],"pubmed_title":["Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia."],"pmcid":["PMC9148595"],"pubmed_authors":["Bakhashab S","Filimban N","Dallol A","Alqahtani MH","Bajouh OS","Batarfi AA"],"additional_accession":[]},"is_claimable":false,"name":"Polycystic ovary syndrome is linked with the fat mass obesity (FTO) gene variants rs17817449 and rs1421085 in western Saudi Arabia.","description":"Polycystic ovary syndrome (PCOS) is characterised by infertility, obesity, insulin resistance and clinical and/or biochemical signs of hyperandrogenism. Obesity is known to be correlated with PCOS causing ovulatory dysfunction and hormone imbalances. Moreover, fat mass and the obesity gene (FTO) were linked with obesity and PCOS. Therefore, it is of interest to determine the genotype and allele frequency for three FTO variants - rs17817449 (G/T), rs1421085 (C/T) and rs8050136 (A/C) -in western Saudi population. 95 PCOS patients and 94 controls were recruited for this study. The genetic variants were assayed using real-time polymerase chain reaction using TaqMan genotyping assays. The chi-squared test was applied to investigate the difference between single nucleotide polymorphisms on PCOS ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T19:31:48.452Z","creation":"2025-02-19T02:58:23.64Z"},"accession":"S-EPMC9148595","cross_references":{"pubmed":["35655906"],"doi":["10.6026/97320630017904"]}}