{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu M"],"funding":["NHLBI NIH HHS"],"pagination":["443-451"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9149111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(6)"],"pubmed_abstract":["Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure."],"journal":["Trends in molecular medicine"],"pubmed_title":["Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias."],"pmcid":["PMC9149111"],"funding_grant_id":["R01 HL104025"],"pubmed_authors":["Kang GJ","Liu M","Dudley SC"],"additional_accession":[]},"is_claimable":false,"name":"Preventing unfolded protein response-induced ion channel dysregulation to treat arrhythmias.","description":"Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-04T21:07:45.216Z","creation":"2025-04-04T21:07:45.216Z"},"accession":"S-EPMC9149111","cross_references":{"pubmed":["35414478"],"doi":["10.1016/j.molmed.2022.03.006"]}}