biostudies-literatureAronoff JEIntramural NIH HHSNHLBI NIH HHSNIMHD NIH HHS28-36https://www.ebi.ac.uk/biostudies/studies/S-EPMC9149129biostudies-literatureUnknown103African American adults suffer disproportionately from several non-communicable and infectious diseases. Among numerous contributing factors, perceived discrimination is considered a stressor for members of historically marginalized groups that contributes to health risk, although biological pathways are incompletely understood. Previous studies have reported associations between stress and both an up-regulation of non-specific (innate) inflammation and down-regulation of specific (adaptive) immunity. While associations between perceived discrimination and markers of inflammation have been explored, it is unclear if this is part of an overall shift that also includes down-regulated adaptive immunity. Relying on a large cross-section of African American adults (n = 3,319) from the Jackson HBrain, behavior, and immunityAssociations between perceived discrimination and immune cell composition in the Jackson Heart Study.PMC9149129HHSN268201800015IHHSN268201800012CF31 HL159910HHSN268201800011CHHSN268201800012IHHSN268201800011IHHSN268201800014IHHSN268201800013IZIA MD000019HHSN268201800010IT32 HL129982HHSN268201800014CGlover LMSims MReiner AForde ATMcDade TWAronoff JEQuinn EBfalseAssociations between perceived discrimination and immune cell composition in the Jackson Heart Study.African American adults suffer disproportionately from several non-communicable and infectious diseases. Among numerous contributing factors, perceived discrimination is considered a stressor for members of historically marginalized groups that contributes to health risk, although biological pathways are incompletely understood. Previous studies have reported associations between stress and both an up-regulation of non-specific (innate) inflammation and down-regulation of specific (adaptive) immunity. While associations between perceived discrimination and markers of inflammation have been explored, it is unclear if this is part of an overall shift that also includes down-regulated adaptive immunity. Relying on a large cross-section of African American adults (n = 3,319) from the Jackson H2022-01-01T00:00:00Z2022 Jul2025-04-26T07:37:54.992Z2025-04-06T12:22:13.172ZS-EPMC91491293538134810.1016/j.bbi.2022.03.017