{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Song J"],"pubmed_abstract":["Tumor necrosis factor alpha (TNF-α) is a crucial factor in the control of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with <i>Mycobacterium marinum</i> (<i>Mm</i>)-a close relative of <i>Mtb</i>-upregulated the expression of E3 ubiquitin ligase FBXW7. Specific silencing FBXW7 with small interfering RNA (siRNA) significantly elevates TNF-α expression and eventually promotes the elimination of intr"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["851197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9149249"],"repository":["biostudies-literature"],"pubmed_title":["E3 Ligase FBXW7 Facilitates <i>Mycobacterium</i> Immune Evasion by Modulating TNF-α Expression."],"pmcid":["PMC9149249"],"pubmed_authors":["Wen X","Zhang D","Ding C","Li D","Chao J","Hu X","Wang D","Zhang L","Han S","Jin Z","Song J","Yan B","Gonzales J","Yu X","Via LE","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"E3 Ligase FBXW7 Facilitates <i>Mycobacterium</i> Immune Evasion by Modulating TNF-α Expression.","description":"Tumor necrosis factor alpha (TNF-α) is a crucial factor in the control of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with <i>Mycobacterium marinum</i> (<i>Mm</i>)-a close relative of <i>Mtb</i>-upregulated the expression of E3 ubiquitin ligase FBXW7. Specific silencing FBXW7 with small interfering RNA (siRNA) significantly elevates TNF-α expression and eventually promotes the elimination of intr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T07:29:00.173Z","creation":"2025-04-06T12:19:52.931Z"},"accession":"S-EPMC9149249","cross_references":{"pubmed":["35651754"],"doi":["10.3389/fcimb.2022.851197"]}}