biostudies-literatureUnknown12Song JTumor necrosis factor alpha (TNF-α) is a crucial factor in the control of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with <i>Mycobacterium marinum</i> (<i>Mm</i>)-a close relative of <i>Mtb</i>-upregulated the expression of E3 ubiquitin ligase FBXW7. Specific silencing FBXW7 with small interfering RNA (siRNA) significantly elevates TNF-α expression and eventually promotes the elimination of intrFrontiers in cellular and infection microbiology851197https://www.ebi.ac.uk/biostudies/studies/S-EPMC9149249biostudies-literatureE3 Ligase FBXW7 Facilitates <i>Mycobacterium</i> Immune Evasion by Modulating TNF-α Expression.PMC9149249Wen XZhang DDing CLi DChao JHu XWang DZhang LHan SJin ZSong JYan BGonzales JYu XVia LESong YfalseE3 Ligase FBXW7 Facilitates <i>Mycobacterium</i> Immune Evasion by Modulating TNF-α Expression.Tumor necrosis factor alpha (TNF-α) is a crucial factor in the control of <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production in a variety of ways to evade antituberculosis (anti-TB) immunity as well as facilitate immune escape. However, the mechanisms by which TNF-α expression in host cells is modulated to the benefit of mycobacteria is still an interesting topic and needs further study. Here, we report that macrophages infected with <i>Mycobacterium marinum</i> (<i>Mm</i>)-a close relative of <i>Mtb</i>-upregulated the expression of E3 ubiquitin ligase FBXW7. Specific silencing FBXW7 with small interfering RNA (siRNA) significantly elevates TNF-α expression and eventually promotes the elimination of intr2022-01-01T00:00:00Z20222025-04-26T07:29:00.173Z2025-04-06T12:19:52.931ZS-EPMC91492493565175410.3389/fcimb.2022.851197