biostudies-literatureUnknown21(1)Wang J<h4>Background</h4>Appropriate iodine intake for adults is essential to reduce the prevalence of thyroid diseases, but there is little research data on iodine requirement of Chinese population. This study aimed to explore the iodine requirement of young adults to maintain a healthy status based on 'overflow theory'.<h4>Methods</h4>Iodine-balance experiment has been performed in this project. We conducted an 18-day study consisted of a 6-day acclimation period and 3 consecutive experimental stages in 37 Chinese healthy young adults (23 female and 14 male). Each stage was consumed for 4 days. Strictly-controlled low-iodine intake diets were provided for adults in the first period, an egg or 125mL milk was added in the second and third period, respectively. The dietary samples, 24-h urine speNutrition journal35https://www.ebi.ac.uk/biostudies/studies/S-EPMC9150309biostudies-literatureExploration of the lower threshold of iodine intake in Southern Chinese young adults based on 'overflow theory' in an iodine balance study.PMC9150309Tan HYang LZhang HPiao JWang JXu JLiu XLi WYang XLi YMao DLu JYu WHong WfalseExploration of the lower threshold of iodine intake in Southern Chinese young adults based on 'overflow theory' in an iodine balance study.<h4>Background</h4>Appropriate iodine intake for adults is essential to reduce the prevalence of thyroid diseases, but there is little research data on iodine requirement of Chinese population. This study aimed to explore the iodine requirement of young adults to maintain a healthy status based on 'overflow theory'.<h4>Methods</h4>Iodine-balance experiment has been performed in this project. We conducted an 18-day study consisted of a 6-day acclimation period and 3 consecutive experimental stages in 37 Chinese healthy young adults (23 female and 14 male). Each stage was consumed for 4 days. Strictly-controlled low-iodine intake diets were provided for adults in the first period, an egg or 125mL milk was added in the second and third period, respectively. The dietary samples, 24-h urine spe2022-01-01T00:00:00Z2022 May2025-04-04T09:41:29.69Z2025-04-04T09:41:29.69ZS-EPMC91503093564468410.1186/s12937-022-00775-z