biostudies-literatureUnknown13Petrova D<i>Nepeta nuda</i> (catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of <i>N. nuda</i> using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the <i>N. nuda</i> metabolic adjustment operating under variable environments. Through comparative analysis of wild-grown and <i>in vitro</i> cultivated plants, we assessed the change in phenolic and iridoid compounds, and the associated immune activities. The wild-grown plants from different Bulgarian locations contained variable amounts of phenolic compounds manifested by a general increase in flowers, as compared to leaves, while a strong reductFrontiers in plant science866777https://www.ebi.ac.uk/biostudies/studies/S-EPMC9150856biostudies-literatureCatmint (<i>Nepeta nuda</i> L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.PMC9150856Tosheva AAtanassov AShishkova KMisic DPetrova DGasic UKapchina-Toteva VMantovska DYordanova ZBonchev GVassileva VYocheva LHinkov ARogova MPaunov MTodorov DChaneva GZhiponova MIvanova LfalseCatmint (<i>Nepeta nuda</i> L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.<i>Nepeta nuda</i> (catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of <i>N. nuda</i> using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the <i>N. nuda</i> metabolic adjustment operating under variable environments. Through comparative analysis of wild-grown and <i>in vitro</i> cultivated plants, we assessed the change in phenolic and iridoid compounds, and the associated immune activities. The wild-grown plants from different Bulgarian locations contained variable amounts of phenolic compounds manifested by a general increase in flowers, as compared to leaves, while a strong reduct2022-01-01T00:00:00Z20222025-04-26T07:27:37.875Z2025-04-06T12:19:29.612ZS-EPMC91508563565176610.3389/fpls.2022.866777