biostudies-literatureUnknown22(1)Nguyen HV<h4>Background</h4>Xpert MTB/Rif, a molecular test to detect tuberculosis (TB), has been proven to have high sensitivity and specificity when compared with liquid culture in clinical settings. However, little is known about its performance in community TB screening.<h4>Methods</h4>In Vietnam, a national TB prevalence survey was conducted in 2017. Survey participants who screened positive by chest X-ray, cough symptoms and/or recent history of tuberculosis were requested to provide at least two sputum samples that were tested for Mycobacterium tuberculosis by Xpert MTB/Rif G4 (Xpert) and BACTEC MGIT960 culture (MGIT).<h4>Results</h4>There were 4,649 eligible participants provided both samples for testing. Among them, 236 (5.1%) participants tested positive for TB by Xpert, 244 (5.3%) testedBMC infectious diseases506https://www.ebi.ac.uk/biostudies/studies/S-EPMC9153144biostudies-literatureDiscordant results of Xpert MTB/Rif assay and BACTEC MGIT 960 liquid culture to detect Mycobacterium tuberculosis in community screening in Vietnam.PMC9153144Nguyen HVde Haas PCobelens FGJVan Nguyen HHuyen PTTNguyen NVNguyen HBMirtskhulava VTiemersma EWFinlay AfalseDiscordant results of Xpert MTB/Rif assay and BACTEC MGIT 960 liquid culture to detect Mycobacterium tuberculosis in community screening in Vietnam.<h4>Background</h4>Xpert MTB/Rif, a molecular test to detect tuberculosis (TB), has been proven to have high sensitivity and specificity when compared with liquid culture in clinical settings. However, little is known about its performance in community TB screening.<h4>Methods</h4>In Vietnam, a national TB prevalence survey was conducted in 2017. Survey participants who screened positive by chest X-ray, cough symptoms and/or recent history of tuberculosis were requested to provide at least two sputum samples that were tested for Mycobacterium tuberculosis by Xpert MTB/Rif G4 (Xpert) and BACTEC MGIT960 culture (MGIT).<h4>Results</h4>There were 4,649 eligible participants provided both samples for testing. Among them, 236 (5.1%) participants tested positive for TB by Xpert, 244 (5.3%) tested2022-01-01T00:00:00Z2022 May2025-05-29T19:01:21.525Z2024-10-19T08:33:59.188ZS-EPMC91531443564193610.1186/s12879-022-07481-5