{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Piccirillo G"],"pubmed_abstract":["As recently reported, elevated fasting glucose plasma level constitutes a risk factor for 30-day total mortality in acutely decompensated chronic heart failure (CHF). Aim of this study was to evaluate the 30-day mortality risk in decompensated CHF patients by fasting glucose plasma level and some repolarization ECG markers.<h4>Method</h4>A total of 164 decompensated CHF patients (M/F: 94/71; mean age, 83 ± 10 years) were studied; Tend (Te), QT interval (QT) and 5 min of ECG recordings were obtained, studying mean, SD and normalized index of the abovementioned ECG intervals. These repolarization variables and fasting glucose were analyzed to assess the 30-day mortality risk among these patients.<h4>Results</h4>Thirty-day mortality rate was 21%, deceased subjects showed a significant increase in N terminal-pro-brain natriuretic peptide (<i>P</i> < 0.001), higher sensitivity cardiac troponin, fasting glucose, creatinine clearance, QTSD, QTVN, Te mean, TeSD and TeVN than the survivals. Multivariable regression analysis reported that fasting glucose (hazard ratio, 1.59; 95% confidence interval, 1.09-2.10; <i>P</i> < 0.01), Te mean (hazard ratio, 1.03; 95% confidence interval, 1.01-1.05; <i>P</i> < 0.01) and QTSD (hazard ratio, 1.17; 95% confidence interval, 1.01-1.36; <i>P</i> < 0.05) were significantly related to higher mortality risk, whereas only fasting glucose (hazard ratio, 1.84; 95% confidence interval, 1.12-3.02; <i>P</i> < 0.05) and Te mean (hazard ratio, 1.07; 95% confidence interval, 1.02-1.11; <i>P</i> < 0.01) were associated to cardiovascular mortality.<h4>Conclusion</h4>Data suggest that two simple, inexpensive, noninvasive markers, as fasting glucose and Te, were capable to stratify the short-term total and cardiovascular mortality risk in acutely decompensated CHF."],"journal":["Cardiovascular endocrinology & metabolism"],"pagination":["e0264"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9155175"],"repository":["biostudies-literature"],"pubmed_title":["Glucose dysregulation and repolarization variability markers are short-term mortality predictors in decompensated heart failure."],"pmcid":["PMC9155175"],"pubmed_authors":["Carnovale M","Corrao A","Moscucci F","Magri D","Di Diego I","Sciomer S","Lospinuso I","Piccirillo G","Rossi P"],"additional_accession":[]},"is_claimable":false,"name":"Glucose dysregulation and repolarization variability markers are short-term mortality predictors in decompensated heart failure.","description":"As recently reported, elevated fasting glucose plasma level constitutes a risk factor for 30-day total mortality in acutely decompensated chronic heart failure (CHF). Aim of this study was to evaluate the 30-day mortality risk in decompensated CHF patients by fasting glucose plasma level and some repolarization ECG markers.<h4>Method</h4>A total of 164 decompensated CHF patients (M/F: 94/71; mean age, 83 ± 10 years) were studied; Tend (Te), QT interval (QT) and 5 min of ECG recordings were obtained, studying mean, SD and normalized index of the abovementioned ECG intervals. These repolarization variables and fasting glucose were analyzed to assess the 30-day mortality risk among these patients.<h4>Results</h4>Thirty-day mortality rate was 21%, deceased subjects showed a significant increase in N terminal-pro-brain natriuretic peptide (<i>P</i> < 0.001), higher sensitivity cardiac troponin, fasting glucose, creatinine clearance, QTSD, QTVN, Te mean, TeSD and TeVN than the survivals. Multivariable regression analysis reported that fasting glucose (hazard ratio, 1.59; 95% confidence interval, 1.09-2.10; <i>P</i> < 0.01), Te mean (hazard ratio, 1.03; 95% confidence interval, 1.01-1.05; <i>P</i> < 0.01) and QTSD (hazard ratio, 1.17; 95% confidence interval, 1.01-1.36; <i>P</i> < 0.05) were significantly related to higher mortality risk, whereas only fasting glucose (hazard ratio, 1.84; 95% confidence interval, 1.12-3.02; <i>P</i> < 0.05) and Te mean (hazard ratio, 1.07; 95% confidence interval, 1.02-1.11; <i>P</i> < 0.01) were associated to cardiovascular mortality.<h4>Conclusion</h4>Data suggest that two simple, inexpensive, noninvasive markers, as fasting glucose and Te, were capable to stratify the short-term total and cardiovascular mortality risk in acutely decompensated CHF.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-25T16:52:48.338Z","creation":"2025-02-19T04:04:49.992Z"},"accession":"S-EPMC9155175","cross_references":{"pubmed":["35664451"],"doi":["10.1097/XCE.0000000000000264"]}}