{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sonni I"],"funding":["NCI NIH HHS"],"pagination":["847-854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9157724"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(6)"],"pubmed_abstract":["The role of prostate-specific membrane antigen (PSMA)-targeted PET in comparison to multiparametric MRI (mpMRI) in the evaluation of intraprostatic cancer foci is not well defined. The aim of our study was to compare the diagnostic performance of <sup>68</sup>Ga-PSMA-11 PET/CT (PSMA PET/CT), mpMRI, and PSMA PET/CT + mpMRI using 3 independent masked readers for each modality and with histopathology as the gold standard in the detection, intraprostatic localization, and determination of local extension of primary prostate cancer. <b>Methods:</b> Patients with intermediate- or high-risk prostate cancer who underwent PSMA PET/CT as part of a prospective trial (NCT03368547) and mpMRI before radical prostatectomy were included. Each imaging modality was interpreted by 3 independent readers who w"],"journal":["Journal of nuclear medicine : official publication, Society of Nuclear Medicine"],"pubmed_title":["Head-to-Head Comparison of <sup>68</sup>Ga-PSMA-11 PET/CT and mpMRI with a Histopathology Gold Standard in the Detection, Intraprostatic Localization, and Determination of Local Extension of Primary Prostate Cancer: Results from a Prospective Single-Center Imaging Trial."],"pmcid":["PMC9157724"],"funding_grant_id":["P30 CA016042","P50 CA211015"],"pubmed_authors":["Sisk AE","Bahri S","Armstrong WR","Sonni I","Elashoff D","Felker ER","Czernin J","Suvannarerg V","Reiter RE","Raman SS","Lenis AT","Tubtawee T","Eiber M","Grogan T","Calais J","Allen-Auerbach M"],"additional_accession":[]},"is_claimable":false,"name":"Head-to-Head Comparison of <sup>68</sup>Ga-PSMA-11 PET/CT and mpMRI with a Histopathology Gold Standard in the Detection, Intraprostatic Localization, and Determination of Local Extension of Primary Prostate Cancer: Results from a Prospective Single-Center Imaging Trial.","description":"The role of prostate-specific membrane antigen (PSMA)-targeted PET in comparison to multiparametric MRI (mpMRI) in the evaluation of intraprostatic cancer foci is not well defined. The aim of our study was to compare the diagnostic performance of <sup>68</sup>Ga-PSMA-11 PET/CT (PSMA PET/CT), mpMRI, and PSMA PET/CT + mpMRI using 3 independent masked readers for each modality and with histopathology as the gold standard in the detection, intraprostatic localization, and determination of local extension of primary prostate cancer. <b>Methods:</b> Patients with intermediate- or high-risk prostate cancer who underwent PSMA PET/CT as part of a prospective trial (NCT03368547) and mpMRI before radical prostatectomy were included. Each imaging modality was interpreted by 3 independent readers who w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-03T22:34:58.739Z","creation":"2024-10-16T03:47:34.169Z"},"accession":"S-EPMC9157724","cross_references":{"pubmed":["34649942"],"doi":["10.2967/jnumed.121.262398"]}}