biostudies-literatureZurnadzhy LJapan Society for the Promotion of Science882727https://www.ebi.ac.uk/biostudies/studies/S-EPMC9159157biostudies-literatureUnknown9With time after the Chernobyl accident, the number of papillary thyroid carcinomas (PTCs) driven by the BRAF^V600E oncoprotein is growing in patients exposed to radiation at a young age. Clinicopathological associations of BRAF^V600E in PTCs from patients with internal radiation history have not been sufficiently studied so far. This work analyzes the structural characteristics, proliferative activity, invasive features, clinical information, and dosimetric data in the BRAF^V600E-positive and BRAF^V600E-negative PTCs from the Ukrainian patients exposed to Chernobyl radiation and treated over 30 years after the accident. The study included 428 PTCs from patients aged 4-49 years at surgery who lived in the six northern regions of Ukraine most contaminaFrontiers in medicineClinicopathological Implications of the <i>BRAF</i> ^{<i>V</i>600<i>E</i>} Mutation in Papillary Thyroid Carcinoma of Ukrainian Patients Exposed to the Chernobyl Radiation in Childhood: A Study for 30 Years After the Accident.PMC915915719K0747119KK0267000120KK0217Bolgov MMasiuk SSaenko VAChernyshov SYamashita SZurnadzhy LBogdanova TMitsutake NIto MTronko MRogounovitch TIfalseClinicopathological Implications of the <i>BRAF</i> ^{<i>V</i>600<i>E</i>} Mutation in Papillary Thyroid Carcinoma of Ukrainian Patients Exposed to the Chernobyl Radiation in Childhood: A Study for 30 Years After the Accident.With time after the Chernobyl accident, the number of papillary thyroid carcinomas (PTCs) driven by the BRAF^V600E oncoprotein is growing in patients exposed to radiation at a young age. Clinicopathological associations of BRAF^V600E in PTCs from patients with internal radiation history have not been sufficiently studied so far. This work analyzes the structural characteristics, proliferative activity, invasive features, clinical information, and dosimetric data in the BRAF^V600E-positive and BRAF^V600E-negative PTCs from the Ukrainian patients exposed to Chernobyl radiation and treated over 30 years after the accident. The study included 428 PTCs from patients aged 4-49 years at surgery who lived in the six northern regions of Ukraine most contamina2022-01-01T00:00:00Z20222025-04-04T19:12:35.766Z2024-11-13T12:16:42.67ZS-EPMC91591573566533810.3389/fmed.2022.882727