{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van Chen T"],"funding":["Bộ Giáo dục và Ðào tạo"],"pagination":["5655-5675"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9159386"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(9)"],"pubmed_abstract":["<i>Distichochlamys citrea</i> M.F. Newman (commonly known as \"Black Ginger\") is an endemic plant to Vietnam and has been extensively exploited by folk medication for treatments of infection-related diseases and diabetes. In this work, its rhizomes were subjected to fractionated extraction, phytochemical examination, evaluation of antioxidant effect by DDPH free radical neutralization, and inhibitory activity toward <i>α</i>-glucosidase. The compositional components were subjected to in silico screening, including density functional theory calculation, molecular docking simulation, physicochemical analysis, and pharmacokinetic regression. In the trials, EtOAc fraction is found as the bioactive part of most effectiveness, regarding both antioxidant effect (IC<sub>50</sub> = 90.27 µg mL<sup>-"],"journal":["Chemicke zvesti"],"pubmed_title":["Antioxidant activity and <i>α</i>-glucosidase inhibitability of <i>Distichochlamys citrea</i> M.F. Newman rhizome fractionated extracts: in vitro and <i>in silico</i> screenings."],"pmcid":["PMC9159386"],"funding_grant_id":["B2021-DHH-13"],"pubmed_authors":["Ho DV","Nhung NTA","Cuong TD","Triet NT","Bui TQ","Van Hue N","Bao NC","Van Chen T","Quy PT","Van Tuan L"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant activity and <i>α</i>-glucosidase inhibitability of <i>Distichochlamys citrea</i> M.F. Newman rhizome fractionated extracts: in vitro and <i>in silico</i> screenings.","description":"<i>Distichochlamys citrea</i> M.F. Newman (commonly known as \"Black Ginger\") is an endemic plant to Vietnam and has been extensively exploited by folk medication for treatments of infection-related diseases and diabetes. In this work, its rhizomes were subjected to fractionated extraction, phytochemical examination, evaluation of antioxidant effect by DDPH free radical neutralization, and inhibitory activity toward <i>α</i>-glucosidase. The compositional components were subjected to in silico screening, including density functional theory calculation, molecular docking simulation, physicochemical analysis, and pharmacokinetic regression. In the trials, EtOAc fraction is found as the bioactive part of most effectiveness, regarding both antioxidant effect (IC<sub>50</sub> = 90.27 µg mL<sup>-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T20:25:49.973Z","creation":"2024-10-16T11:46:49.096Z"},"accession":"S-EPMC9159386","cross_references":{"pubmed":["35669698"],"doi":["10.1007/s11696-022-02273-2"]}}