{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mill J"],"funding":["NIA NIH HHS","NIDDK NIH HHS","Foundation for the National Institutes of Health","National Institute on Aging"],"pagination":["1-17"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9159642"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(1)"],"pubmed_abstract":["Alzheimer's disease (AD) is the leading cause of dementia in the aging population, but despite extensive research, there is no consensus on the biological cause of AD. While AD research is dominated by protein/peptide-centric research based on the amyloid hypothesis, a theory that designates dysfunction in beta-amyloid production, accumulation, or disposal as the primary cause of AD, many studies focus on metabolomics as a means of understanding the biological processes behind AD progression. In this review, we discuss mass spectrometry (MS)-based AD metabolomics studies, including sample type and preparation, mass spectrometry specifications, and data analysis, as well as biological insights gleaned from these studies, with the hope of informing future AD metabolomic studies."],"journal":["Phenomics (Cham, Switzerland)"],"pubmed_title":["Recent Advances in Understanding of Alzheimer's Disease Progression through Mass Spectrometry-Based Metabolomics."],"pmcid":["PMC9159642"],"funding_grant_id":["R21AG065728","T32AG000213","RF1AG052324","R01 DK071801","R21 AG065728","T32 AG000213","P30 AG062715","RF1 AG052324"],"pubmed_authors":["Mill J","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Recent Advances in Understanding of Alzheimer's Disease Progression through Mass Spectrometry-Based Metabolomics.","description":"Alzheimer's disease (AD) is the leading cause of dementia in the aging population, but despite extensive research, there is no consensus on the biological cause of AD. While AD research is dominated by protein/peptide-centric research based on the amyloid hypothesis, a theory that designates dysfunction in beta-amyloid production, accumulation, or disposal as the primary cause of AD, many studies focus on metabolomics as a means of understanding the biological processes behind AD progression. In this review, we discuss mass spectrometry (MS)-based AD metabolomics studies, including sample type and preparation, mass spectrometry specifications, and data analysis, as well as biological insights gleaned from these studies, with the hope of informing future AD metabolomic studies.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2026-06-03T18:35:34.291Z","creation":"2026-04-30T03:12:04.153Z"},"accession":"S-EPMC9159642","cross_references":{"pubmed":["35656096"],"doi":["10.1007/s43657-021-00036-9"]}}