{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(6)"],"submitter":["Li Q"],"pubmed_abstract":["A number of emerging studies in field of immune metabolism have indicated that cellular metabolic reprograming serves as a major administrator in maintaining the viability and functions of both tumor cells and immune cells. As one of the most important immunosuppressive cells in tumor stroma, myeloid-derived suppressor cells (MDSCs) dynamically orchestrate their metabolic pathways in response to the complicated tumor microenvironment (TME), a process that consequently limits the therapeutic effectiveness of anti-cancer treatment modalities. In this context, the metabolic vulnerabilities of MDSCs could be exploited as a novel immune metabolic checkpoint upon which to intervene for promoting the efficacy of immunotherapy. Here, we have discussed about recent studies highlighting the importan"],"journal":["Acta pharmacologica Sinica"],"pagination":["1337-1348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9160034"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy."],"pmcid":["PMC9160034"],"pubmed_authors":["Li Q","Xiang M"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic reprograming of MDSCs within tumor microenvironment and targeting for cancer immunotherapy.","description":"A number of emerging studies in field of immune metabolism have indicated that cellular metabolic reprograming serves as a major administrator in maintaining the viability and functions of both tumor cells and immune cells. As one of the most important immunosuppressive cells in tumor stroma, myeloid-derived suppressor cells (MDSCs) dynamically orchestrate their metabolic pathways in response to the complicated tumor microenvironment (TME), a process that consequently limits the therapeutic effectiveness of anti-cancer treatment modalities. In this context, the metabolic vulnerabilities of MDSCs could be exploited as a novel immune metabolic checkpoint upon which to intervene for promoting the efficacy of immunotherapy. Here, we have discussed about recent studies highlighting the importan","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-26T23:01:08.369Z","creation":"2025-04-06T17:24:18.836Z"},"accession":"S-EPMC9160034","cross_references":{"pubmed":["34561553"],"doi":["10.1038/s41401-021-00776-4"]}}